HIP2 (Human) Recombinant Protein (P02)
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More Files
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Specification
Product Description
Human HIP2 full-length ORF ( NP_005330.1, 1 a.a. - 200 a.a.) recombinant protein with GST-tag at N-terminal.
Sequence
MANIAVQRIKREFKEVLKSEETSKNQIKVDLVDENFTELRGEIAGPPDTPYEGGRYQLEIKIPETYPFNPPKVRFITKIWHPNISSVTGAICLDILKDQWAAAMTLRTVLLSLQALLAAAEPDDPQDAVVANQYKQNPEMFKQTARLWAHVYAGAPVSSPEYTKKIENLCAMGFDRNAVIVALSSKSWDVETATELLLSN
Host
Wheat Germ (in vitro)
Theoretical MW (kDa)
48.8
Preparation Method
Purification
Glutathione Sepharose 4 Fast Flow
Quality Control Testing
12.5% SDS-PAGE Stained with Coomassie Blue.
Storage Buffer
50 mM Tris-HCI, 10 mM reduced Glutathione, pH=8.0 in the elution buffer.
Storage Instruction
Store at -80°C. Aliquot to avoid repeated freezing and thawing.
Note
Best use within three months from the date of receipt of this protein.
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Applications
Enzyme-linked Immunoabsorbent Assay
Western Blot (Recombinant protein)
Antibody Production
Protein Array
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Gene Info — UBE2K
Entrez GeneID
3093GeneBank Accession#
NM_005339.3Protein Accession#
NP_005330.1Gene Name
UBE2K
Gene Alias
DKFZp564C1216, DKFZp686J24237, E2-25K, HIP2, HYPG, LIG
Gene Description
ubiquitin-conjugating enzyme E2K (UBC1 homolog, yeast)
Omim ID
602846Gene Ontology
HyperlinkGene Summary
The protein encoded by this gene belongs to the ubiquitin-conjugating enzyme family. This protein interacts with RING finger proteins, and it can ubiquitinate huntingtin, the gene product for Huntington's disease. Known functions for this protein include a role in aggregate formation of expanded polyglutamine proteins and the suppression of apoptosis in polyglutamine diseases, a role in the dislocation of newly synthesized MHC class I heavy chains from the endoplasmic reticulum, and involvement in foam cell formation. Multiple transcript variants encoding different isoforms have been identified for this gene. [provided by RefSeq
Other Designations
huntingtin interacting protein 2|ubiquitin carrier protein|ubiquitin-conjugating enzyme E2-25 KDA|ubiquitin-conjugating enzyme E2-25K|ubiquitin-protein ligase
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Interactome
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Pathway
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