MS4A2 DNAxPab
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Specification
Product Description
Rabbit polyclonal antibody raised against a partial-length human MS4A2 DNA using DNAx™ Immune technology.
Technology
Immunogen
Extracellular membrane domain (ECD) human DNA
Host
Rabbit
Reactivity
Human
Purification
Protein A
Quality Control Testing
Antibody reactive against mammalian transfected lysate.
Storage Buffer
In 1x PBS, pH 7.4
Storage Instruction
Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.
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Applications
Western Blot (Transfected lysate)
Immunofluorescence (Transfected cell)
Flow Cytometry (Transfected cell)
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Gene Info — MS4A2
Entrez GeneID
2206GeneBank Accession#
NM_000139.2Protein Accession#
NP_000130.1Gene Name
MS4A2
Gene Alias
APY, ATOPY, FCER1B, FCERI, IGEL, IGER, IGHER, MS4A1
Gene Description
membrane-spanning 4-domains, subfamily A, member 2 (Fc fragment of IgE, high affinity I, receptor for; beta polypeptide)
Gene Ontology
HyperlinkGene Summary
The allergic response involves the binding of allergen to receptor-bound IgE followed by cell activation and the release of mediators responsible for the manifestations of allergy. The IgE-receptor, a tetramer composed of an alpha, beta, and 2 disulfide-linked gamma chains, is found on the surface of mast cells and basophils. This gene encodes the beta subunit of the high affinity IgE receptor which is a member of the membrane-spanning 4A gene family. Members of this nascent protein family are characterized by common structural features and similar intron/exon splice boundaries and display unique expression patterns among hematopoietic cells and nonlymphoid tissues. This family member is localized to 11q12, among a cluster of family members. Alternative splicing results in multiple transcript variants encoding different isoforms
Other Designations
Fc IgE receptor, beta chain|Fc epsilon receptor I beta-chain|Fc-epsilon receptor I beta-chain|High affinity immunoglobulin epsilon receptor beta-subunit (FcERI) (IgE Fc receptor, beta-subunit) (Fc epsilon receptor I beta-chain)|IgE responsiveness (atopic)
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Interactome
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Pathway
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Disease
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