DR1 DNAxPab
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Specification
Product Description
Rabbit polyclonal antibody raised against a full-length human DR1 DNA using DNAx™ Immune technology.
Technology
Immunogen
Full-length human DNA
Sequence
MASSSGNDDDLTIPRAAINKMIKETLPNVRVANDARELVVNCCTEFIHLISSEANEICNKSEKKTISPEHVIQALESLGFGSYISEVKEVLQECKTVALKRRKASSRLENLGIPEEELLRQQQELFAKARQQQAELAQQEWLQMQQAAQQAQLAAASASASNQAGSSQDEEDDDDI
Host
Rabbit
Reactivity
Human
Purification
Protein A
Quality Control Testing
Antibody reactive against mammalian transfected lysate.
Storage Buffer
In 1x PBS, pH 7.4
Storage Instruction
Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.
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Applications
Western Blot (Transfected lysate)
Immunofluorescence (Transfected cell)
Flow Cytometry (Transfected cell)
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Gene Info — DR1
Entrez GeneID
1810GeneBank Accession#
NM_001938.2Protein Accession#
NP_001929.1Gene Name
DR1
Gene Alias
NC2, NC2-BETA
Gene Description
down-regulator of transcription 1, TBP-binding (negative cofactor 2)
Omim ID
601482Gene Ontology
HyperlinkGene Summary
This gene encodes a TBP- (TATA box-binding protein) associated phosphoprotein that represses both basal and activated levels of transcription. The encoded protein is phosphorylated in vivo and this phosphorylation affects its interaction with TBP. This protein contains a histone fold motif at the amino terminus, a TBP-binding domain, and a glutamine- and alanine-rich region. The binding of DR1 repressor complexes to TBP-promoter complexes may establish a mechanism in which an altered DNA conformation, together with the formation of higher order complexes, inhibits the assembly of the preinitiation complex and controls the rate of RNA polymerase II transcription. [provided by RefSeq
Other Designations
OTTHUMP00000012556|OTTHUMP00000012557|down-regulator of transcription 1
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Interactome
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Disease
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