DNASE1L1 monoclonal antibody (M02), clone 4E8
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Specification
Product Description
Mouse monoclonal antibody raised against a full length recombinant DNASE1L1.
Immunogen
DNASE1L1 (AAH01561, 18 a.a. ~ 302 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Sequence
AFRICAFNAQRLTLAKVAREQVMDTLVRILARCDIMVLQEVVDSSGSAIPLLLRELNRFDGSGPYSTLSSPQLGRSTYMETYVYFYRSHKTQVLSSYVYNDEDDVFAREPFVAQFSLPSNVLPSLVLVPLHTTPKAVEKELNALYDVFLEVSQHWQSKDVILLGDFNADCASLTKKRLDKLELRTEPGFHWVIADGEDTTVRASTHCTYDRVVLHGERCRSLLHTAAAFDFPTSFQLTEEEALNISDHYPVEVELKLSQAHSVQPLSLTVLLLLSLLSPQLCPAA
Host
Mouse
Reactivity
Human
Interspecies Antigen Sequence
Rat (72)
Isotype
IgG1 Kappa
Quality Control Testing
Antibody Reactive Against Recombinant Protein.
Western Blot detection against Immunogen (57.09 KDa) .
Storage Buffer
In 1x PBS, pH 7.4
Storage Instruction
Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.
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Applications
Western Blot (Transfected lysate)
Western Blot analysis of DNASE1L1 expression in transfected 293T cell line by DNASE1L1 monoclonal antibody (M02), clone 4E8.
Lane 1: DNASE1L1 transfected lysate(33.9 KDa).
Lane 2: Non-transfected lysate.
Western Blot (Recombinant protein)
Sandwich ELISA (Recombinant protein)
Detection limit for recombinant GST tagged DNASE1L1 is approximately 0.3ng/ml as a capture antibody.ELISA
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Gene Info — DNASE1L1
Entrez GeneID
1774GeneBank Accession#
BC001561Protein Accession#
AAH01561Gene Name
DNASE1L1
Gene Alias
DNAS1L1, DNASEX, DNL1L, XIB
Gene Description
deoxyribonuclease I-like 1
Omim ID
300081Gene Ontology
HyperlinkGene Summary
This gene encodes a member of the deoxyribonuclease family and the protein shows high sequence similarity to lysosomal DNase I. Alternate transcriptional splice variants, encoding the same protein, have been characterized. [provided by RefSeq
Other Designations
DNase I, lysosomal-like|DNase I-like, muscle-specific|DNase X|OTTHUMP00000031940|OTTHUMP00000031941|OTTHUMP00000031943|OTTHUMP00000032113
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Interactome
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Disease
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Publication Reference
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Ubiquitous membrane-bound DNase activity in podosomes and invadopodia.
Kaushik Pal, Yuanchang Zhao, Yongliang Wang, Xuefeng Wang.
The Journal of Cell Biology 2021 Jul; 220(7):e202008079.
Application:IF, Human, THP-1 cells.
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Optical sensor revealed abnormal nuclease spatial activity on cancer cell membrane.
Wang Y, Zhao Y, Sarkar A, Wang X.
Journal of Biophotonics 2018 Nov; e201800351.
Application:IF, Human, MDA-MB-231 cells.
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Ubiquitous membrane-bound DNase activity in podosomes and invadopodia.
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