CYP2C19 purified MaxPab mouse polyclonal antibody (B01P)
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Specification
Product Description
Mouse polyclonal antibody raised against a full-length human CYP2C19 protein.
Immunogen
CYP2C19 (AAI11847.1, 1 a.a. ~ 490 a.a) full-length human protein.
Sequence
MDPFVVLVLCLSCLLLLSIWRQSSGRGKLPPGPTPLPVIGNILQIDIKDVSKSLTNLSKIYGPVFTLYFGLERMVVLHGYEVVKEALIDLGEEFSGRGHFPLAERANRGFGIVFSNGKRWKEIRRFSLMTLRNFGMGKRSIEDRVQEEARCLVEELRKTKASPCDPTFILGCAPCNVICSIIFQKRFDYKDQQFLNLMEKLNENIRIVSTPWIQICNNFPTIIDYFPGTHNKLLKNLAFMESDILEKVKEHQESMDINNPRDFIDCFLIKMEKEKQNQQSEFTIENLVITAADLLGAGTETTSTTLRYALLLLLKHPEVTAKVQEEIERVVGRNRSPCMQDRGHMPYTDAVVHEVQRYIDLIPTSLPHAVTCDVKFRNYLIPKGTTILTSLTSVLHDNKEFPNPEMFDPRHFLDEGGNFKKSNYFMPFSAGKRICVGEGLARMELFLFLTFILQNFNLKSLIDPKDLDTTPVVNGFASVPPFYQLCFIPV
Host
Mouse
Reactivity
Human
Interspecies Antigen Sequence
Rat (74%)
Quality Control Testing
Antibody reactive against mammalian transfected lysate.
Storage Buffer
In 1x PBS, pH 7.4
Storage Instruction
Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.
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Applications
Western Blot (Transfected lysate)
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Gene Info — CYP2C19
Entrez GeneID
1557GeneBank Accession#
BC111846.2Protein Accession#
AAI11847.1Gene Name
CYP2C19
Gene Alias
CPCJ, CYP2C, P450C2C, P450IIC19
Gene Description
cytochrome P450, family 2, subfamily C, polypeptide 19
Omim ID
124020Gene Ontology
HyperlinkGene Summary
This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and is known to metabolize many xenobiotics, including the anticonvulsive drug mephenytoin, omeprazole, diazepam and some barbiturates. Polymorphism within this gene is associated with variable ability to metabolize mephenytoin, known as the poor metabolizer and extensive metabolizer phenotypes. The gene is located within a cluster of cytochrome P450 genes on chromosome 10q24. [provided by RefSeq
Other Designations
OTTHUMP00000020132|OTTHUMP00000059588|S-mephenytoin 4-hydroxylase|cytochrome P-450 II C|cytochrome P450, subfamily IIC (mephenytoin 4-hydroxylase), polypeptide 19|flavoprotein-linked monooxygenase|mephenytoin 4'-hydroxylase|microsomal monooxygenase|xenobi
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Interactome
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Pathway
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Disease
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