CYP2A6 purified MaxPab mouse polyclonal antibody (B01P)
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More Files
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Specification
Product Description
Mouse polyclonal antibody raised against a full-length human CYP2A6 protein.
Immunogen
CYP2A6 (AAH96255.1, 1 a.a. ~ 494 a.a) full-length human protein.
Sequence
MLASGMLLVALLVCLTVMVLMSVWQQRKSKGKLPPGPTPLPFIGNYLQLNTEQMYNSLMKISERYGPVFTIHLGPRRVVVLCGHDAVREALVDQAEEFSGRGEQATFDWVFKGYGVVFSNGERAKQLRRFSIATLRDFGVGKRGIEERIQEEAGFLIDAHRGTGGANIDPTFFLSRTVSNVISSIVFGDRFDYKDKEFLSLLRMMLGIFQFTSTSTGQLYEMFSSVMKHLPGPQQQAFQLLQGLEDFIAKKVEHNQRTLDPNSPRDFIDSFLIRMQEEEKNPNTEFYLKNLVMTTLNLFIGGTETVSTTLRYGFLLLMKHPEVEAKVHEEIDRVIGKNRQPKFEDRAKMPYMEAVIHEIQRFGDVIPMSLARRVKKDTKFRDFFLPKGTEVYPMLGSVLRDPSFFSNPQDFNPQHFLNEKGQFKKSDAFVPFSIGKRNCFGEGLARMELFLFFTTVMQNFRLKSSQSPKDIDVSPKHVGFATIPRNYTMSFLPR
Host
Mouse
Reactivity
Human
Quality Control Testing
Antibody reactive against mammalian transfected lysate.
Storage Buffer
In 1x PBS, pH 7.4
Storage Instruction
Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.
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Applications
Western Blot (Tissue lysate)
CYP2A6 MaxPab polyclonal antibody. Western Blot analysis of CYP2A6 expression in human liver.Western Blot (Transfected lysate)
Western Blot analysis of CYP2A6 expression in transfected 293T cell line (H00001548-T01) by CYP2A6 MaxPab polyclonal antibody.
Lane 1: CYP2A6 transfected lysate(54.34 KDa).
Lane 2: Non-transfected lysate.
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Gene Info — CYP2A6
Entrez GeneID
1548GeneBank Accession#
BC096255.1Protein Accession#
AAH96255.1Gene Name
CYP2A6
Gene Alias
CPA6, CYP2A, CYP2A3, P450C2A, P450PB
Gene Description
cytochrome P450, family 2, subfamily A, polypeptide 6
Gene Ontology
HyperlinkGene Summary
This gene, CYP2A6, encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and its expression is induced by phenobarbital. The enzyme is known to hydroxylate coumarin, and also metabolizes nicotine, aflatoxin B1, nitrosamines, and some pharmaceuticals. Individuals with certain allelic variants are said to have a poor metabolizer phenotype, meaning they do not efficiently metabolize coumarin or nicotine. This gene is part of a large cluster of cytochrome P450 genes from the CYP2A, CYP2B and CYP2F subfamilies on chromosome 19q. The gene was formerly referred to as CYP2A3; however, it has been renamed CYP2A6. [provided by RefSeq
Other Designations
coumarin 7-hydroxylase|cytochrome P450, subfamily IIA (phenobarbital-inducible), polypeptide 3|cytochrome P450, subfamily IIA (phenobarbital-inducible), polypeptide 6|flavoprotein-linked monooxygenase|xenobiotic monooxygenase
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Interactome
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Pathway
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Disease
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Publication Reference
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Association analysis of CYP2A6 genotypes and haplotypes with 5-fluorouracil formation from tegafur in human liver microsomes.
Wang H, Bian T, Liu D, Jin T, Chen Y, Lin A, Chen C.
Pharmacogenomics 2011 Apr; 12(4):481.
Application:WB, Human, Human liver microsomes.
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Association analysis of CYP2A6 genotypes and haplotypes with 5-fluorouracil formation from tegafur in human liver microsomes.
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