CNTFR DNAxPab
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Specification
Product Description
Rabbit polyclonal antibody raised against a partial-length human CNTFR DNA using DNAx™ Immune technology.
Technology
Immunogen
Extracellular membrane domain (ECD) human DNA
Host
Rabbit
Reactivity
Human
Purification
Protein A
Quality Control Testing
Antibody reactive against mammalian transfected lysate.
Storage Buffer
In 1x PBS, pH 7.4
Storage Instruction
Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.
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Applications
Western Blot (Transfected lysate)
Immunofluorescence (Transfected cell)
Flow Cytometry (Transfected cell)
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Gene Info — CNTFR
Entrez GeneID
1271GeneBank Accession#
BC001492.2Protein Accession#
AAH01492.1Gene Name
CNTFR
Gene Alias
MGC1774
Gene Description
ciliary neurotrophic factor receptor
Omim ID
118946Gene Ontology
HyperlinkGene Summary
This gene encodes a hematopoeitin/interferon-class receptor belonging to the cytokine superfamily of receptors. The encoded gene product represents the CNTF-specific alpha subunit of a heterotrimer forming the CNTF receptor complex, which also includes LIFR and gp130. The receptor is attached to the membrane by a glycosyl-phosphatidylinositol linkage and contains an immunoglobulin-like C2-type domain and a fibronectin type-III domain. Signal transduction requires that CNTF bind first to this alpha component, which permits the recruitment of gp130 and LIFR beta to form the tripartite receptor complex. Signal transduction stimulates gene expression, cell survival or differentiation in a variety of neuronal cell types. Alternative splicing has been observed at this locus and two variants, both encoding the same protein, have been identified. [provided by RefSeq
Other Designations
CNTFR alpha|OTTHUMP00000021270|OTTHUMP00000021271|ciliary neurotrophic factor receptor alpha
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Interactome
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