CKMT1B 293T Cell Transient Overexpression Lysate(Denatured)
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More Files
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Specification
Transfected Cell Line
293T
Plasmid
pCMV-CKMT1B full-length
Host
Human
Theoretical MW (kDa)
47
Interspecies Antigen Sequence
Mouse (97); Rat (97)
Quality Control Testing
Transient overexpression cell lysate was tested with Anti-CKMT1B antibody (H00001159-B01) by Western Blots.
SDS-PAGE Gel
CKMT1B transfected lysate
Western Blot
Lane 1: CKMT1B transfected lysate ( 47 KDa).
Lane 2: Non-transfected lysate.Storage Buffer
1X Sample Buffer (50 mM Tris-HCl, 2% SDS, 10% glycerol, 300 mM 2-mercaptoethanol, 0.01% Bromophenol blue)
Storage Instruction
Store at -80°C. Aliquot to avoid repeated freezing and thawing.
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Applications
Western Blot
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Gene Info — CKMT1B
Entrez GeneID
1159GeneBank Accession#
NM_020990Protein Accession#
NP_066270Gene Name
CKMT1B
Gene Alias
CKMT, CKMT1, UMTCK
Gene Description
creatine kinase, mitochondrial 1B
Omim ID
123290Gene Ontology
HyperlinkGene Summary
Mitochondrial creatine (MtCK) kinase is responsible for the transfer of high energy phosphate from mitochondria to the cytosolic carrier, creatine. It belongs to the creatine kinase isoenzyme family. It exists as two isoenzymes, sarcomeric MtCK and ubiquitous MtCK, encoded by separate genes. Mitochondrial creatine kinase occurs in two different oligomeric forms: dimers and octamers, in contrast to the exclusively dimeric cytosolic creatine kinase isoenzymes. Many malignant cancers with poor prognosis have shown overexpression of ubiquitous mitochondrial creatine kinase; this may be related to high energy turnover and failure to eliminate cancer cells via apoptosis. Ubiquitous mitochondrial creatine kinase has 80% homology with the coding exons of sarcomeric mitochondrial creatine kinase. Two genes located near each other on chromosome 15 have been identified which encode identical mitochondrial creatine kinase proteins. [provided by RefSeq
Other Designations
OTTHUMP00000066275|acidic-type mitochondrial creatine kinase|creatine kinase, mitochondrial 1 (ubiquitous)|ubiquitous mitochondrial creatine kinase
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