ATOX1 (Human) Recombinant Protein (Q01)
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Specification
Product Description
Human ATOX1 partial ORF ( NP_004036, 1 a.a. - 68 a.a.) recombinant protein with GST-tag at N-terminal.
Sequence
MPKHEFSVDMTCGGCAEAVSRVLNKLGGVKYDIDLPNKKVCIESEHSMDTLLATLKKTGKTVSYLGLE
Host
Wheat Germ (in vitro)
Theoretical MW (kDa)
33.22
Interspecies Antigen Sequence
Mouse (88); Rat (89)
Preparation Method
Purification
Glutathione Sepharose 4 Fast Flow
Quality Control Testing
12.5% SDS-PAGE Stained with Coomassie Blue.
Storage Buffer
50 mM Tris-HCI, 10 mM reduced Glutathione, pH=8.0 in the elution buffer.
Storage Instruction
Store at -80°C. Aliquot to avoid repeated freezing and thawing.
Note
Best use within three months from the date of receipt of this protein.
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Applications
Enzyme-linked Immunoabsorbent Assay
Western Blot (Recombinant protein)
Antibody Production
Protein Array
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Gene Info — ATOX1
Entrez GeneID
475GeneBank Accession#
NM_004045Protein Accession#
NP_004036Gene Name
ATOX1
Gene Alias
ATX1, HAH1, MGC138453, MGC138455
Gene Description
ATX1 antioxidant protein 1 homolog (yeast)
Omim ID
602270Gene Ontology
HyperlinkGene Summary
This gene encodes a copper chaperone that plays a role in copper homeostasis by binding and transporting cytosolic copper to ATPase proteins in the trans-Golgi network for later incorporation to the ceruloplasmin. This protein also functions as an antioxidant against superoxide and hydrogen peroxide, and therefore, may play a significant role in cancer carcinogenesis. Because of its cytogenetic location, this gene represents a candidate gene for 5q-syndrome. [provided by RefSeq
Other Designations
antioxidant protein 1|copper transport protein|metal transport protein
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Interactome
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Disease
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