Products

Western Blot (Transfected lysate)

ELISA

Entrez GeneID

GeneBank Accession#

Gene Name

ANK3

Gene Alias

ANKYRIN-G, FLJ45464

Gene Description

ankyrin 3, node of Ranvier (ankyrin G)

Omim ID

Gene Ontology

Gene Summary

Ankyrins are a family of proteins that are believed to link the integral membrane proteins to the underlying spectrin-actin cytoskeleton and play key roles in activities such as cell motility, activation, proliferation, contact, and the maintenance of specialized membrane domains. Multiple isoforms of ankyrin with different affinities for various target proteins are expressed in a tissue-specific, developmentally regulated manner. Most ankyrins are typically composed of three structural domains: an amino-terminal domain containing multiple ankyrin repeats; a central region with a highly conserved spectrin binding domain; and a carboxy-terminal regulatory domain which is the least conserved and subject to variation. Ankyrin 3 is an immunologically distinct gene product from ankyrins 1 and 2, and was originally found at the axonal initial segment and nodes of Ranvier of neurons in the central and peripheral nervous systems. Alternatively spliced variants may be expressed in other tissues. Although multiple transcript variants encoding several different isoforms have been found for this gene, the full-length nature of only two have been characterized. [provided by RefSeq

Other Designations

ankyrin 3|ankyrin G119|ankyrin-3, node of Ranvier