ABAT 293T Cell Transient Overexpression Lysate(Denatured)
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More Files
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SDS-PAGE Gel
ABAT transfected lysate.
Western Blot
Lane 1: ABAT transfected lysate ( 56.40 KDa)
Lane 2: Non-transfected lysate.
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Specification
Transfected Cell Line
293T
Plasmid
pCMV-ABAT full-length
Host
Human
Theoretical MW (kDa)
56.4
Interspecies Antigen Sequence
Mouse (91); Rat (92)
Quality Control Testing
Transient overexpression cell lysate was tested with Anti-ABAT antibody (H00000018-D01P) by Western Blots.
SDS-PAGE Gel
ABAT transfected lysate.
Western Blot
Lane 1: ABAT transfected lysate ( 56.40 KDa)
Lane 2: Non-transfected lysate.Storage Buffer
1X Sample Buffer (50 mM Tris-HCl, 2% SDS, 10% glycerol, 300 mM 2-mercaptoethanol, 0.01% Bromophenol blue)
Storage Instruction
Store at -80°C. Aliquot to avoid repeated freezing and thawing.
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Applications
Western Blot
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Gene Info — ABAT
Entrez GeneID
18GeneBank Accession#
NM_000663.3Protein Accession#
NP_000654.2Gene Name
ABAT
Gene Alias
FLJ17813, GABA-AT, GABAT, NPD009
Gene Description
4-aminobutyrate aminotransferase
Omim ID
137150Gene Ontology
HyperlinkGene Summary
4-aminobutyrate aminotransferase (ABAT) is responsible for catabolism of gamma-aminobutyric acid (GABA), an important, mostly inhibitory neurotransmitter in the central nervous system, into succinic semialdehyde. The active enzyme is a homodimer of 50-kD subunits complexed to pyridoxal-5-phosphate. The protein sequence is over 95% similar to the pig protein. GABA is estimated to be present in nearly one-third of human synapses. ABAT in liver and brain is controlled by 2 codominant alleles with a frequency in a Caucasian population of 0.56 and 0.44. The ABAT deficiency phenotype includes psychomotor retardation, hypotonia, hyperreflexia, lethargy, refractory seizures, and EEG abnormalities. Multiple alternatively spliced transcript variants encoding the same protein isoform have been found for this gene. [provided by RefSeq
Other Designations
GABA aminotransferase|GABA transferase|gamma-amino-N-butyrate transaminase
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Interactome
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Pathway
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Disease
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