Products

In situ Proximity Ligation Assay (Cell)

Entrez GeneID

Gene Name

PTK2

Gene Alias

FADK, FAK, FAK1, pp125FAK

Gene Description

PTK2 protein tyrosine kinase 2

Omim ID

Gene Ontology

Gene Summary

This gene encodes a cytoplasmic protein tyrosine kinase which is found concentrated in the focal adhesions that form between cells growing in the presence of extracellular matrix constituents. The encoded protein is a member of the FAK subfamily of protein tyrosine kinases but lacks significant sequence similarity to kinases from other subfamilies. Activation of this gene may be an important early step in cell growth and intracellular signal transduction pathways triggered in response to certain neural peptides or to cell interactions with the extracellular matrix. At least four transcript variants encoding four different isoforms have been found for this gene, but the full-length natures of only two of them have been determined. [provided by RefSeq

Other Designations

focal adhesion kinase 1

Entrez GeneID

Gene Name

PIAS1

Gene Alias

DDXBP1, GBP, GU/RH-II, MGC141878, MGC141879, ZMIZ3

Gene Description

protein inhibitor of activated STAT, 1

Omim ID

Gene Ontology

Gene Summary

This gene encodes a member of the mammalian PIAS [protein inhibitor of activated STAT-1 (signal transducer and activator of transcription-1)] family. This member contains a putative zinc-binding motif and a highly acidic region. It inhibits STAT1-mediated gene activation and the DNA binding activity, binds to Gu protein/RNA helicase II/DEAD box polypeptide 21, and interacts with androgen receptor (AR). It functions in testis as a nuclear receptor transcriptional coregulator and may have a role in AR initiation and maintenance of spermatogenesis. [provided by RefSeq

Other Designations

AR interacting protein|DEAD/H (Asp-Glu-Ala-Asp/His) box binding protein 1|protein inhibitor of activated STAT-1|zinc finger, MIZ-type containing 3