SMURF1 & ECSIT Protein Protein Interaction Antibody Pair
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More Files
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Representative image of Proximity Ligation Assay of protein-protein interactions between SMURF1 and ECSIT. HeLa cells were stained with anti-SMURF1 rabbit purified polyclonal antibody 1:1200 and anti-ECSIT mouse monoclonal antibody 1:50. Each red dot represents the detection of protein-protein interaction complex. The images were analyzed using an optimized freeware (BlobFinder) download from The Centre for Image Analysis at Uppsala University.
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Specification
Product Description
This protein protein interaction antibody pair set comes with two antibodies to detect the protein-protein interaction, one against the SMURF1 protein, and the other against the ECSIT protein for use in in situ Proximity Ligation Assay. See Publication Reference below.
Reactivity
Human
Quality Control Testing
Protein protein interaction immunofluorescence result.
Representative image of Proximity Ligation Assay of protein-protein interactions between SMURF1 and ECSIT. HeLa cells were stained with anti-SMURF1 rabbit purified polyclonal antibody 1:1200 and anti-ECSIT mouse monoclonal antibody 1:50. Each red dot represents the detection of protein-protein interaction complex. The images were analyzed using an optimized freeware (BlobFinder) download from The Centre for Image Analysis at Uppsala University.
Supplied Product
Antibody pair set content:
1. SMURF1 rabbit purified polyclonal antibody (100 ug)
2. ECSIT mouse monoclonal antibody (40 ug)
*Reagents are sufficient for at least 30-50 assays using recommended protocols.Storage Instruction
Store reagents of the antibody pair set at -20°C or lower. Please aliquot to avoid repeated freeze thaw cycle. Reagents should be returned to -20°C storage immediately after use.
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Applications
In situ Proximity Ligation Assay (Cell)
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Gene Info — ECSIT
Entrez GeneID
51295Gene Name
ECSIT
Gene Alias
SITPEC
Gene Description
ECSIT homolog (Drosophila)
Omim ID
608388Gene Ontology
HyperlinkOther Designations
evolutionarily conserved signaling intermediate in Toll pathway|likely ortholog of mouse signaling intermediate in Toll pathway evolutionarily conserved|signaling intermediate in Toll pathway evolutionarily conserved ortholog|signaling intermediate in Tol
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Gene Info — SMURF1
Entrez GeneID
57154Gene Name
SMURF1
Gene Alias
KIAA1625
Gene Description
SMAD specific E3 ubiquitin protein ligase 1
Omim ID
605568Gene Ontology
HyperlinkGene Summary
This gene encodes a ubiquitin ligase that is specific for receptor-regulated SMAD proteins in the bone morphogenetic protein (BMP) pathway. A similar protein in Xenopus is involved in embryonic pattern formation. Alternative splicing results in multiple transcript variants encoding different isoforms. An additional transcript variant has been identified, but its full length sequence has not been determined. [provided by RefSeq
Other Designations
E3 ubiquitin ligase SMURF1|Smad ubiquitination regulatory factor 1|Smad-specific E3 ubiquitin ligase 1
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Interactome
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Pathway
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