Western blot analysis of ALDOA polyclonal antibody (Cat # PAB2568) in CEM cell line lysates (35 ug/lane). ALDOA (arrow) was detected using the purified polyclonal antibody (1 : 60 dilution).
Formalin-fixed and paraffin-embedded human lung carcinomareacted with ALDOA polyclonal antibody (Cat # PAB2568), which was peroxidase-conjugated to the secondary antibody, followed by AEC staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.
This gene product, Aldolase A (fructose-bisphosphate aldolase) is a glycolytic enzyme that catalyzes the reversible conversion of fructose-1,6-bisphosphate to glyceraldehyde 3-phosphate and dihydroxyacetone phosphate. Three aldolase isozymes (A, B, and C), encoded by three different genes, are differentially expressed during development. Aldolase A is found in the developing embryo and is produced in even greater amounts in adult muscle. Aldolase A expression is repressed in adult liver, kidney and intestine and similar to aldolase C levels in brain and other nervous tissue. Aldolase A deficiency has been associated with myopathy and hemolytic anemia. Alternative splicing of this gene results in multiple transcript variants which encode the same protein. [provided by RefSeq
Other Designations:
aldolase A,fructose-1,6-bisphosphate triosephosphate-lyase,fructose-bisphosphate aldolase A
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