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CD8A polyclonal antibody
Katalog # : PAB16612
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100 ug
EUR € 289
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Product Description:
Rabbit polyclonal antibody raised against recombinant CD8A.
Immunogen:
Recombinant protein corresponding to human CD8A.
Reactivity:
Human, Mouse, Rat
Recommend Usage:
ELISA (1-2 ug/mL) Immunohistochemistry (2-10 ug/mL) Western Blot (2-10 ug/mL) The optimal working dilution should be determined by the end user.
Storage Buffer:
Lyophilized from PBS
Storage Instruction:
Store at -20°C on dry atmosphere. After reconstitution with deionized water, store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.
1.
Recombinant yellow fever vaccine virus 17D expressing simian immunodeficiency virus SIVmac239 gag induces SIV-specific CD8+ T-cell responses in rhesus macaques. Bonaldo MC, Martins MA, Rudersdorf R, Mudd PA, Sacha JB, Piaskowski SM, Costa Neves PC, Veloso de Santana MG, Vojnov L, Capuano S 3rd, Rakasz EG, Wilson NA, Fulkerson J, Sadoff JC, Watkins DI, Galler R.J Virol. 2010 Apr;84(7):3699-706. Epub 2010 Jan 20.
2.
Extralymphoid CD8+ T cells resident in tissue from simian immunodeficiency virus SIVmac239{Delta}nef-vaccinated macaques suppress SIVmac239 replication ex vivo. Greene JM, Lhost JJ, Burwitz BJ, Budde ML, Macnair CE, Weiker MK, Gostick E, Friedrich TC, Broman KW, Price DA, O'Connor SL, O'Connor DH.J Virol. 2010 Apr;84(7):3362-72. Epub 2010 Jan 20.
Immunohistochemistry
Immunohistochemical analysis of CD8A expressing mouse ovarian vascular endothelial cells. CD8A polyclonal antibody (Cat ID # PAB16612) was used as primary antibody, dilution 1 : 200.
Gene Alias:
CD8,Leu2,MAL,p32
Gene Description:
CD8a molecule
Gene Summary:
The CD8 antigen is a cell surface glycoprotein found on most cytotoxic T lymphocytes that mediates efficient cell-cell interactions within the immune system. The CD8 antigen acts as a corepressor with the T-cell receptor on the T lymphocyte to recognize antigens displayed by an antigen presenting cell (APC) in the context of class I MHC molecules. The coreceptor functions as either a homodimer composed of two alpha chains, or as a heterodimer composed of one alpha and one beta chain. Both alpha and beta chains share significant homology to immunoglobulin variable light chains. This gene encodes the CD8 alpha chain isoforms. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq
Other Designations:
CD8 antigen alpha polypeptide,CD8 antigen, alpha polypeptide (p32),Leu2 T-lymphocyte antigen,OKT8 T-cell antigen,T cell co-receptor,T-cell antigen Leu2,T-cell surface glycoprotein CD8 alpha chain,T-lymphocyte differentiation antigen T8/Leu-2,T8 T-cell ant