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TP53 (phospho S37) polyclonal antibody
Katalog # : PAB0564
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100 ug
EUR € 305
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Product Description: Rabbit polyclonal antibody raised against synthetic phosphopeptide of TP53.
Immunogen: Synthetic phosphopeptide (conjugated with KLH) corresponding to residues surrounding S37 of human TP53.
Purification: Protein G purification
Recommend Usage: ELISA (1:1000)
Storage Buffer: In PBS (0.09% sodium azide)
Storage Instruction: Store at 4°C. For long term storage store at -20°C.
Note: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
2.
Identification of SCN3B as a novel p53-inducible proapoptotic gene.
Western Blot (Cell lysate) The TP53 (phospho S37) polyclonal antibody (Cat # PAB0564) is used in Western blot to detect Phospho-TP53-S37 in Ramos (left) and Jurkat (right) cell lysates.
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) Formalin-fixed and paraffin-embedded human cancer tissue reacted with TP53 (phospho S37) polyclonal antibody (Cat # PAB0564) which was peroxidase-conjugated to the secondary antibody followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated. BC = breast carcinoma.
Dot Blot (Peptide) Dot blot analysis of TP53 (phospho S37) polyclonal antibody (Cat # PAB0564) on nitrocellulose membrane. 50 ng of Phospho-peptide or Non Phospho-peptide per dot were adsorbed. Antibody working concentrations are 0.5 ug/mL.
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
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Protein Accession#:
NP_000537;P04637
Gene Alias: FLJ92943,LFS1,TRP53,p53
Gene Description: tumor protein p53
Gene Summary: This gene encodes tumor protein p53, which responds to diverse cellular stresses to regulate target genes that induce cell cycle arrest, apoptosis, senescence, DNA repair, or changes in metabolism. p53 protein is expressed at low level in normal cells and at a high level in a variety of transformed cell lines, where it's believed to contribute to transformation and malignancy. p53 is a DNA-binding protein containing transcription activation, DNA-binding, and oligomerization domains. It is postulated to bind to a p53-binding site and activate expression of downstream genes that inhibit growth and/or invasion, and thus function as a tumor suppressor. Mutants of p53 that frequently occur in a number of different human cancers fail to bind the consensus DNA binding site, and hence cause the loss of tumor suppressor activity. Alterations of this gene occur not only as somatic mutations in human malignancies, but also as germline mutations in some cancer-prone families with Li-Fraumeni syndrome. Multiple p53 variants due to alternative promoters and multiple alternative splicing have been found. These variants encode distinct isoforms, which can regulate p53 transcriptional activity. [provided by RefSeq
Other Designations: p53 antigen,p53 transformation suppressor,p53 tumor suppressor,phosphoprotein p53,transformation-related protein 53
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2 Neuroma, Acoustic Neuropsychological Tests Neutropenia Nijmegen Breakage Syndrome Nose Neoplasms Obesity Obesity Occupational Diseases Ocular Hypertension Oligodendroglioma Oligospermia Optic Atrophy, Hereditary, Leber Oral Submucous Fibrosis Oropharyngeal Neoplasms Osteoarthritis Osteosarcoma Ovarian cancer Ovarian Neoplasms Pancreatic cancer Pancreatic Neoplasms Papilloma, Choroid Plexus Papillomavirus Infections Pemphigus Penile Neoplasms Peptic Ulcer Peritoneal Neoplasms Pharyngeal Neoplasms Postoperative Complications Precancerous Conditions Prostate cancer Prostatic Hyperplasia Prostatic Intraepithelial Neoplasia Prostatic Neoplasms Psoriasis Pterygium Pulmonary Disease, Chronic Obstructive Pulmonary Fibrosis Radiation Injuries Radiodermatitis Rectal Neoplasms Recurrence Roseolovirus Infections Sarcoma Sarcoma, Kaposi Schizophrenia Schizophrenia Skin Diseases Skin Neoplasms Small Cell Lung Carcinoma Spinal Dysraphism Stomach Neoplasms Stomach Ulcer Subarachnoid Hemorrhage Substance-Related Disorders Sunburn The p53 tumor suppressor protein Thyroid Diseases Thyroid Neoplasms Thyroiditis, Autoimmune Tobacco Use Disorder Tongue Neoplasms Tumor Virus Infections Uremia Urinary Bladder Neoplasms Urologic Diseases Uterine Cervical Diseases Uterine Cervical Dysplasia Uterine Cervical Neoplasms Uterine Neoplasms Waldenstrom Macroglobulinemia Wegener Granulomatosis Werner syndrome
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