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- Home > Products > Monoclonal Ab > Human > Membrane > Receptor > TLR4 monoclonal antibody, clone HTA125 (NaN3 Free)
TLR4 monoclonal antibody, clone HTA125 (NaN3 Free)
- Katalog # : MAB0072
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- 100 ug
- EUR € 289
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- Specification
- Product Description:
- Mouse monoclonal antibody raised against full length recombinant TLR4.
- Immunogen:
- Recombinant protein corresponding to full length human TLR4.
- Host:
- Mouse
- Reactivity:
- Human
- Form:
- Liquid
- Isotype:
- IgG2a
- Recommend Usage:
- The optimal working dilution should be determined by the end user.
- Storage Buffer:
- In PBS
- Storage Instruction:
- Store at 4°C. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.
- Publication Reference
- 1.
- TLR2 and TLR4 expression on the immune cells of tuberculous pleural fluid.
Prabha C, Rajashree P, Sulochana DD.Immunol Lett. 2008 Apr 15;117(1):26-34. Epub 2007 Dec 3.
- 2.
- Intracellular signaling mechanisms regulating toll-like receptor-mediated activation of eosinophils.
Wong CK, Cheung PF, Ip WK, Lam CW.Am J Respir Cell Mol Biol. 2007 Jul;37(1):85-96. Epub 2007 Mar 1.
- 3.
- Execution of macrophage apoptosis by PE_PGRS33 of Mycobacterium tuberculosis is mediated by Toll-like receptor 2-dependent release of tumor necrosis factor-alpha.
Basu S, Pathak SK, Banerjee A, Pathak S, Bhattacharyya A, Yang Z, Talarico S, Kundu M, Basu J.J Biol Chem. 2007 Jan 12;282(2):1039-50. Epub 2006 Nov 9.
- 4.
- RANTES modulates TLR4-induced cytokine secretion in human peripheral blood monocytes.
Shahrara S, Park CC, Temkin V, Jarvis JW, Volin MV, Pope RM.J Immunol. 2006 Oct 15;177(8):5077-87.
- 5.
- In celiac disease, a subset of autoantibodies against transglutaminase binds toll-like receptor 4 and induces activation of monocytes.
Zanoni G, Navone R, Lunardi C, Tridente G, Bason C, Sivori S, Beri R, Dolcino M, Valletta E, Corrocher R, Puccetti A.PLoS Med. 2006 Sep;3(9):e358.
- Application Image
- Immunocytochemistry
- Immunofluorescence
- Immunoprecipitation
- Flow Cytometry
- Entrez GeneID:
- 7099
- Gene Name:
- TLR4
- Gene Alias:
- ARMD10,CD284,TOLL,hToll
- Gene Description:
- toll-like receptor 4
- Omim ID:
- 603030
- Gene Ontology:
- Hyperlink
- Gene Summary:
- The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. This receptor is most abundantly expressed in placenta, and in myelomonocytic subpopulation of the leukocytes. It has been implicated in signal transduction events induced by lipopolysaccharide (LPS) found in most gram-negative bacteria. Mutations in this gene have been associated with differences in LPS responsiveness. Also, several transcript variants of this gene have been found, but the protein coding potential of most of them is uncertain. [provided by RefSeq
- Other Designations:
- OTTHUMP00000022807,homolog of Drosophila toll
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