Immunoprecipitation of CBL transfected lysate using anti-CBL MaxPab rabbit polyclonal antibody and Protein A Magnetic Bead (U0007), and immunoblotted with CBL MaxPab mouse polyclonal antibody (B01) (H00000867-B01).
The cbl oncogene was first identified as part of a transforming retrovirus which induces mouse pre-B and pro-B cell lymphomas. As an adaptor protein for receptor protein-tyrosine kinases, it positively regulates receptor protein-tyrosine kinase ubiquitination in a manner dependent upon its variant SH2 and RING finger domains. Ubiquitination of receptor protein-tyrosine kinases terminates signaling by marking active receptors for degradation. [provided by RefSeq