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Amyloid-beta monoclonal antibody, clone McSA1   

  • Katalog # : MAB5669
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  • 100 ug
  • EUR € 375
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    Phone : +49-6221-825877
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  • Specification
  • Product Description:
  • Mouse monoclonal antibody raised against synthetic peptide of Beta Amyloid.
  • Immunogen:
  • A synthetic peptide corresponding to amino acids 1-40 of human APP.
  • Host:
  • Mouse
  • Reactivity:
  • Human
  • Specificity:
  • Progressive deposition of insoluble aggregates of the 39 to 43 amino acid amyloid beta (Abeta) peptide derived from the proteolytic cleavage of the amyloid beta protein precursor (AbetaPP), gives rise to one of the pathological hallmarks of Alzheimer's disease (AD).
  • Form:
  • Lyophilized
  • Isotype:
  • IgG1, kappa
  • Recommend Usage:
  • Immunohistochemistry (1:500)
    Immunocytochemistry (1:500)
    The optimal working dilution should be determined by the end user.
  • Storage Buffer:
  • Lyophilized from culture medium
  • Storage Instruction:
  • Store at 4°C or -20°C on dry atmosphere.
    After reconstitution with water and glycerol (1:1), store at -20°C or -80°C.
    Aliquot to avoid repeated freezing and thawing.
  • Publication Reference
  • Applications
  • Western Blot
  • Immunohistochemistry
  • Immunocytochemistry
  • Immunoprecipitation
  • Application Image
  • Western Blot
  • Immunohistochemistry
  • Immunocytochemistry
  • Immunoprecipitation
  • Gene Information
  • Entrez GeneID:
  • 351
  • Gene Name:
  • APP
  • Gene Alias:
  • AAA,ABETA,ABPP,AD1,APPI,CTFgamma,CVAP,PN2
  • Gene Description:
  • amyloid beta (A4) precursor protein
  • Gene Summary:
  • This gene encodes a cell surface receptor and transmembrane precursor protein that is cleaved by secretases to form a number of peptides. Some of these peptides are secreted and can bind to the acetyltransferase complex APBB1/TIP60 to promote transcriptional activation, while others form the protein basis of the amyloid plaques found in the brains of patients with Alzheimer disease. Mutations in this gene have been implicated in autosomal dominant Alzheimer disease and cerebroarterial amyloidosis (cerebral amyloid angiopathy). Multiple transcript variants encoding several different isoforms have been found for this gene. [provided by RefSeq
  • Other Designations:
  • A4 amyloid protein,amyloid beta A4 protein,amyloid-beta protein,beta-amyloid peptide,cerebral vascular amyloid peptide,peptidase nexin-II,protease nexin-II
  • Interactome
  • Gene Pathway
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