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QPRT monoclonal antibody (M01), clone 5D11
Katalog # : H00023475-M01
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100 ug
EUR € 299
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Product Description:
Mouse monoclonal antibody raised against a partial recombinant QPRT.
Immunogen:
QPRT (NP_055113, 198 a.a. ~ 297 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Sequence:
VEVECSSLQEAVQAAEAGADLVLLDNFKPEELHPTATVLKAQFPSVAVEASGGITLDNLPQFCGPHIDVISMGMLTQAAPALDFSLKLFAKEVAPVPKIH
Quality Control Testing:
Antibody Reactive Against Recombinant Protein. Western Blot detection against Immunogen (36.74 KDa) .
Storage Buffer:
In 1x PBS, pH 7.2
Storage Instruction:
Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.
Western Blot (Cell lysate)
QPRT monoclonal antibody (M01), clone 5D11 Western Blot analysis of QPRT expression in HepG2 ( Cat # L019V1 ).
Protocol Download
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
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Immunoperoxidase of monoclonal antibody to QPRT on formalin-fixed paraffin-embedded human tonsil. [antibody concentration 3 ug/ml]
Protocol Download
Sandwich ELISA (Recombinant protein)
Detection limit for recombinant GST tagged QPRT is approximately 0.03ng/ml as a capture antibody.
Protocol Download
Western Blot (Recombinant protein)
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
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Sandwich ELISA (Recombinant protein)
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Gene Description:
quinolinate phosphoribosyltransferase
Gene Summary:
This gene encodes a key enzyme in catabolism of quinolinate, an intermediate in the tryptophan-nicotinamide adenine dinucleotide pathway. Quinolinate acts as a most potent endogenous exitotoxin to neurons. Elevation of quinolinate levels in the brain has been linked to the pathogenesis of neurodegenerative disorders such as epilepsy, Alzheimer's disease, and Huntington's disease. [provided by RefSeq
Other Designations:
nicotinate-nucleotide pyrophosphorylase (carboxylating)