This gene encodes a component of a multisubunit enzyme (1 mDa MW) that mediates acidification of eukaryotic intracellular organelles. Vacuolar ATPase (V-ATPase) is comprised of a cytosolic V1 (site of the ATP catalytic site) and a transmembrane V0 domain. V-ATPase dependent organelle acidification is necessary for such intracellular processes as protein sorting, zymogen activation, and receptor-mediated endocytosis. The encoded protein of this gene is approximately 45 kD and may assist in the V-ATPase-mediated acidification of neuroendocrine secretory granules. [provided by RefSeq
Other Designations:
ATPase, H+ transporting, lysosomal (vacuolar proton pump), subunit 1,ATPase, H+ transporting, lysosomal interacting protein 1,H-ATPase subunit,OTTHUMP00000032115,V-ATPase S1 accessory protein
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