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- Home > Products > Polyclonal Ab > Phospho-Specific > EIF4EBP1 (phospho S111) polyclonal antibody
EIF4EBP1 (phospho S111) polyclonal antibody
- 目录号 # : PAB8146
- 访问频率 :
- 尺寸
- 价格
- 库存
- 可得性
- 购物车
- 100 ug
- USD $ 335
- order now, ship in 5 days
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- 该价格仅在China有效。请选择国家。
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Phone : +886-2-87511888
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- Specification
- Product Description:
- Rabbit polyclonal antibody raised against synthetic phosphopeptide of EIF4EBP1.
- Immunogen:
- Synthetic phosphopeptide (conjugated with KLH) corresponding to residues surrounding S111 of human EIF4EBP1.
- Host:
- Rabbit
- Reactivity:
- Human
- Form:
- Liquid
- Purification:
- Peptide affinity purification
- Recommend Usage:
- ELISA (1:1000)
Dot Blot (1:500)
The optimal working dilution should be determined by the end user.
- Storage Buffer:
- In PBS (0.09% sodium azide)
- Storage Instruction:
- Store at 4°C. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.
- Note:
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Publication Reference
- 1.
- 4E-binding protein 1: a key molecular "funnel factor" in human cancer with clinical implications.
Armengol G, Rojo F, Castellvi J, Iglesias C, Cuatrecasas M, Pons B, Baselga J, Ramon y Cajal S.Cancer Res. 2007 Aug 15;67(16):7551-5.
- 2.
- PRAS40 is a target for mammalian target of rapamycin complex 1 and is required for signaling downstream of this complex.
Fonseca BD, Smith EM, Lee VH, MacKintosh C, Proud CG.J Biol Chem. 2007 Aug 24;282(34):24514-24. Epub 2007 Jun 29.
- Entrez GeneID:
- 1978
- Protein Accession#:
- NP_004086
- Gene Name:
- EIF4EBP1
- Gene Alias:
- 4E-BP1,4EBP1,BP-1,MGC4316,PHAS-I
- Gene Description:
- eukaryotic translation initiation factor 4E binding protein 1
- Omim ID:
- 602223
- Gene Ontology:
- Hyperlink
- Gene Summary:
- This gene encodes one member of a family of translation repressor proteins. The protein directly interacts with eukaryotic translation initiation factor 4E (eIF4E), which is a limiting component of the multisubunit complex that recruits 40S ribosomal subunits to the 5' end of mRNAs. Interaction of this protein with eIF4E inhibits complex assembly and represses translation. This protein is phosphorylated in response to various signals including UV irradiation and insulin signaling, resulting in its dissociation from eIF4E and activation of mRNA translation. [provided by RefSeq
- Other Designations:
- eIF4E-binding protein 1,phosphorylated heat- and acid-stable protein regulated by insulin 1
- Interactome
