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- Home > Products > Polyclonal Ab > Human > Others > BACE1 polyclonal antibody
BACE1 polyclonal antibody
- 目录号 # : PAB4690
- 访问频率 :
- 尺寸
- 价格
- 库存
- 可得性
- 购物车
- 100 ug
- USD $ 319
- order now, ship in 5 days
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Phone : +886-2-87511888
Fax : +886-2-87511166- 产品会直接装运至客户处。
- Specification
- Product Description:
- Rabbit polyclonal antibody raised against synthetic peptide of BACE1.
- Immunogen:
- A synthetic peptide (conjugated with KLH) corresponding to internal region of human BACE1.
- Host:
- Rabbit
- Reactivity:
- Human, Mouse
- Form:
- Liquid
- Purification:
- Protein G purification
- Recommend Usage:
- ELISA (1:1000)
Western Blot (1:100-500)
Immunohistochemistry (1:50-100)
The optimal working dilution should be determined by the end user.
- Storage Buffer:
- In PBS (0.09% sodium azide)
- Storage Instruction:
- Store at 4°C. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.
- Note:
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Publication Reference
- 1.
- Transcriptional regulation of BACE1, the beta-amyloid precursor protein beta-secretase, by Sp1.
Christensen MA, Zhou W, Qing H, Lehman A, Philipsen S, Song W.Mol Cell Biol. 2004 Jan;24(2):865-74.
- 2.
- The cell adhesion protein P-selectin glycoprotein ligand-1 is a substrate for the aspartyl protease BACE1.
Lichtenthaler SF, Dominguez DI, Westmeyer GG, Reiss K, Haass C, Saftig P, De Strooper B, Seed B.J Biol Chem. 2003 Dec 5;278(49):48713-9. Epub 2003 Sep 24.
- 3.
- Characterization of the ectodomain shedding of the beta-site amyloid precursor protein-cleaving enzyme 1 (BACE1).
Hussain I, Hawkins J, Shikotra A, Riddell DR, Faller A, Dingwall C.J Biol Chem. 2003 Sep 19;278(38):36264-8. Epub 2003 Jul 11.
- Applications
- Western Blot (Tissue lysate)
- The BACE1 polyclonal antibody (Cat # PAB4690) is used in Western blot to detect BACE1 in mouse brain tissue lysate.
- Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
- Formalin-fixed and paraffin-embedded human cancer tissue reacted with BACE1 polyclonal antibody (Cat # PAB4690) , which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry ; clinical relevance has not been evaluated. BC = breast carcinoma.
- Entrez GeneID:
- 23621
- Protein Accession#:
- P56817-2
- Gene Name:
- BACE1
- Gene Alias:
- ASP2,BACE,FLJ90568,HSPC104,KIAA1149
- Gene Description:
- beta-site APP-cleaving enzyme 1
- Omim ID:
- 604252
- Gene Ontology:
- Hyperlink
- Gene Summary:
- Cerebral deposition of amyloid beta peptide is an early and critical feature of Alzheimer's disease. Amyloid beta peptide is generated by proteolytic cleavage of amyloid precursor protein (APP) by two proteases, one of which is the protein encoded by this gene. The encoded protein, a member of the peptidase A1 protein family, is a type I integral membrane glycoprotein and aspartic protease that is found mainly in the Golgi. Four transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq
- Other Designations:
- APP beta-secretase,aspartyl protease 2,beta-secretase,beta-site amyloid beta A4 precursor protein-cleaving enzyme,beta-site amyloid precursor protein cleaving enzyme,memapsin-2,membrane-associated aspartic protease 2,transmembrane aspartic proteinase Asp2
- Interactome
- Gene Pathway
