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PDGFRB polyclonal antibody
- 目录号 # : PAB3375
- 访问频率 :
- 尺寸
- 价格
- 库存
- 可得性
- 购物车
- 100 ug
- USD $ 319
- order now, ship in 5 days
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- 该价格仅在China有效。请选择国家。
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Email : sales@abnova.com
Phone : +886-2-87511888
Fax : +886-2-87511166- 产品会直接装运至客户处。
- Specification
- Product Description:
- Rabbit polyclonal antibody raised against synthetic peptide of PDGFRB.
- Immunogen:
- A synthetic peptide (conjugated with KLH) corresponding to N-terminus of human PDGFRB.
- Host:
- Rabbit
- Reactivity:
- Human
- Form:
- Liquid
- Purification:
- Protein G purification
- Recommend Usage:
- ELISA (1:1000)
Western Blot (1:100-500)
Immunohistochemistry (1:50-100)
Flow cytometry (1:10-50)
The optimal working dilution should be determined by the end user.
- Storage Buffer:
- In PBS (0.09% sodium azide)
- Storage Instruction:
- Store at 4°C. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.
- Note:
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Publication Reference
- 1.
- Platelet-derived growth factor (PDGF) stimulates glucose transport in 3T3-L1 adipocytes overexpressing PDGF receptor by a pathway independent of insulin receptor substrates.
Whiteman EL, Chen JJ, Birnbaum MJ.Endocrinology. 2003 Sep;144(9):3811-20.
- 2.
- YXXM motifs in the PDGF-beta receptor serve dual roles as phosphoinositide 3-kinase binding motifs and tyrosine-based endocytic sorting signals.
Wu H, Windmiller DA, Wang L, Backer JM.J Biol Chem. 2003 Oct 17;278(42):40425-8. Epub 2003 Aug 25.
- 3.
- Beta-platelet-derived growth factor receptor mediates motility and growth of Ewing's sarcoma cells.
Uren A, Merchant MS, Sun CJ, Vitolo MI, Sun Y, Tsokos M, Illei PB, Ladanyi M, Passaniti A, Mackall C, Toretsky JA.Oncogene. 2003 Apr 17;22(15):2334-42.
- Applications
- Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
- Formalin-fixed and paraffin-embedded human cancer tissue reacted with PDGFRB polyclonal antibody (Cat # PAB3375) , which was peroxidase-conjugated to the secondary antibody, followed by AEC staining. This data demonstrates the use of this antibody for immunohistochemistry ; clinical relevance has not been evaluated. BC = breast carcinoma.
- Entrez GeneID:
- 5159
- Protein Accession#:
- P09619
- Gene Name:
- PDGFRB
- Gene Alias:
- CD140B,JTK12,PDGF-R-beta,PDGFR,PDGFR1
- Gene Description:
- platelet-derived growth factor receptor, beta polypeptide
- Gene Ontology:
- Hyperlink
- Gene Summary:
- This gene encodes a cell surface tyrosine kinase receptor for members of the platelet-derived growth factor family. These growth factors are mitogens for cells of mesenchymal origin. The identity of the growth factor bound to a receptor monomer determines whether the functional receptor is a homodimer or a heterodimer, composed of both platelet-derived growth factor receptor alpha and beta polypeptides. This gene is flanked on chromosome 5 by the genes for granulocyte-macrophage colony-stimulating factor and macrophage-colony stimulating factor receptor; all three genes may be implicated in the 5-q syndrome. A translocation between chromosomes 5 and 12, that fuses this gene to that of the translocation, ETV6, leukemia gene, results in chronic myeloproliferative disorder with eosinophilia. [provided by RefSeq
- Other Designations:
- beta platelet-derived growth factor receptor,platelet-derived growth factor receptor beta,soluble PDGFRb variant 1
- Interactome
- Related Disease
- Acute Disease
- Adenocarcinoma
- Alzheimer Disease
- Alzheimer disease
- Cardiovascular Diseases
- Diabetes Complications
- Diabetes Mellitus, Type 2
- Disease Models, Animal
- Edema
- Esophageal Neoplasms
- Genetic Predisposition to Disease
- Hyperparathyroidism, Secondary
- Kidney Failure, Chronic
- Leukemia, Myeloid
- Metabolic Syndrome X
- Neoplasms
- Osteoporosis
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