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CSF1R polyclonal antibody
- 目录号 # : PAB3000
- 访问频率 :
- 尺寸
- 价格
- 库存
- 可得性
- 购物车
- 100 ug
- USD $ 319
- order now, ship in 5 days
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- 该价格仅在China有效。请选择国家。
- 询问我们任何问题
- 付款信息
信用卡 :
Email : sales@abnova.com
Phone : +886-2-87511888
Fax : +886-2-87511166- 产品会直接装运至客户处。
- Specification
- Product Description:
- Rabbit polyclonal antibody raised against synthetic peptide of CSF1R.
- Immunogen:
- A synthetic peptide (conjugated with KLH) corresponding to C-terminus of human CSF1R.
- Host:
- Rabbit
- Reactivity:
- Human
- Form:
- Liquid
- Purification:
- Protein G purification
- Recommend Usage:
- ELISA (1:1000)
Western Blot (1:100-500 Immumnohistochemistry 1:50-100)
The optimal working dilution should be determined by the end user.
- Storage Buffer:
- In PBS (0.09% sodium azide)
- Storage Instruction:
- Store at 4°C. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.
- Note:
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Publication Reference
- 1.
- Epigenetic consequences of AML1-ETO action at the human c-FMS locus.
Follows GA, Tagoh H, Lefevre P, Hodge D, Morgan GJ, Bonifer C.EMBO J. 2003 Jun 2;22(11):2798-809.
- 2.
- C-fms expression correlates with monocytic differentiation in PML-RAR alpha+ acute promyelocytic leukemia.
Riccioni R, Saulle E, Militi S, Sposi NM, Gualtiero M, Mauro N, Mancini M, Diverio D, Lo Coco F, Peschle C, Testa U.Leukemia. 2003 Jan;17(1):98-113.
- 3.
- Vitamin D(3) and analogues modulate the expression of CSF-1 and its receptor in human dendritic cells.
Zhu K, Glaser R, Mrowietz U.Biochem Biophys Res Commun. 2002 Oct 11;297(5):1211-7.
- Applications
- Western Blot (Tissue lysate)
- Western blot analysis of CSF1R polyclonal antibody (Cat # PAB3000) in human placenta. CSF1R (arrow) was detected using purified polyclonal antibody. Secondary HRP-anti-rabbit was used for signal visualization with chemiluminescence.
- Western Blot (Transfected lysate)
- (LEFT) Western blot analysis of CSF1R (arrow) using rabbit CSF1R polyclonal antibody (Cat # PAB3000). 293 cell lysates (2 ug/lane) either nontransfected (Lane 1) or transiently transfected with the CSF1R gene (Lane 2) (Origene Technologies). (RIGHT) Western blot analysis of CSF1R polyclonal antibody (Cat # PAB3000) transiently transfected HEK-293 cell line lysate (1 ug/lane). CSF1R polyclonal antibody (arrow) was detected using the purified polyclonal antibody (1 : 1500 dilution).
- Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
- Formalin-fixed and paraffin-embedded human lung carcinoma tissue reacted with CSF1R polyclonal antibody (Cat # PAB3000) , which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.
- Entrez GeneID:
- 1436
- Protein Accession#:
- P07333
- Gene Name:
- CSF1R
- Gene Alias:
- C-FMS,CD115,CSFR,FIM2,FMS
- Gene Description:
- colony stimulating factor 1 receptor
- Omim ID:
- 164770
- Gene Ontology:
- Hyperlink
- Gene Summary:
- The protein encoded by this gene is the receptor for colony stimulating factor 1, a cytokine which controls the production, differentiation, and function of macrophages. This receptor mediates most if not all of the biological effects of this cytokine. Ligand binding activates the receptor kinase through a process of oligomerization and transphosphorylation. The encoded protein is a tyrosine kinase transmembrane receptor and member of the CSF1/PDGF receptor family of tyrosine-protein kinases. Mutations in this gene have been associated with a predisposition to myeloid malignancy. The first intron of this gene contains a transcriptionally inactive ribosomal protein L7 processed pseudogene oriented in the opposite direction. [provided by RefSeq
- Other Designations:
- CD115 antigen,FMS proto-oncogene,McDonough feline sarcoma viral (v-fms) oncogene homolog,macrophage colony stimulating factor I receptor,soluble CSF1R variant 1
- Interactome
- Related Disease
- Asthma
- Crohn's disease
- Genetic Predisposition to Disease
- Heart Defects, Congenital
- Lung Neoplasms
- Myelodysplastic Syndromes
- Pancreatic cancer
- Pancreatic Neoplasms
- Pulmonary Disease, Chronic Obstructive
- Purpura, Thrombocytopenic, Idiopathic
- Tobacco Use Disorder
- Urinary Bladder Neoplasms
- Werner syndrome
