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DYRK1A polyclonal antibody
- 目录号 # : PAB2932
- 访问频率 :
- 尺寸
- 价格
- 库存
- 可得性
- 购物车
- 100 ug
- USD $ 319
- order now, ship in 5 days
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Phone : +886-2-87511888
Fax : +886-2-87511166- 产品会直接装运至客户处。
- Specification
- Product Description:
- Rabbit polyclonal antibody raised against synthetic peptide of DYRK1A.
- Immunogen:
- A synthetic peptide (conjugated with KLH) corresponding to N-terminus of human DYRK1A.
- Host:
- Rabbit
- Reactivity:
- Human
- Form:
- Liquid
- Purification:
- Protein G purification
- Recommend Usage:
- ELISA (1:1000)
Western Blot (1:100-500)
The optimal working dilution should be determined by the end user.
- Storage Buffer:
- In PBS (0.09% sodium azide)
- Storage Instruction:
- Store at 4°C. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.
- Note:
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Publication Reference
- 1.
- Human minibrain homologue (MNBH/DYRK1): characterization, alternative splicing, differential tissue expression, and overexpression in Down syndrome.
Guimera J, Casas C, Estivill X, Pritchard M.Genomics. 1999 May 1;57(3):407-18.
- 2.
- Sequence characteristics, subcellular localization, and substrate specificity of DYRK-related kinases, a novel family of dual specificity protein kinases.
Becker W, Weber Y, Wetzel K, Eirmbter K, Tejedor FJ, Joost HG.J Biol Chem. 1998 Oct 2;273(40):25893-902.
- 3.
- Identification of two novel 5' noncoding exons in human MNB/DYRK gene and alternatively spliced transcripts.
Wang J, Kudoh J, Shintani A, Minoshima S, Shimizu N.Biochem Biophys Res Commun. 1998 Sep 29;250(3):704-10.
- Entrez GeneID:
- 1859
- Protein Accession#:
- DYRA_HUMAN
- Gene Name:
- DYRK1A
- Gene Alias:
- DYRK,DYRK1,HP86,MNB,MNBH
- Gene Description:
- dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A
- Omim ID:
- 600855
- Gene Ontology:
- Hyperlink
- Gene Summary:
- This gene encodes a member of the Dual-specificity tyrosine phosphorylation-regulated kinase (DYRK) family. This member contains a nuclear targeting signal sequence, a protein kinase domain, a leucine zipper motif, and a highly conservative 13-consecutive-histidine repeat. It catalyzes its autophosphorylation on serine/threonine and tyrosine residues. It may play a significant role in a signaling pathway regulating cell proliferation and may be involved in brain development. This gene is a homolog of Drosophila mnb (minibrain) gene and rat Dyrk gene. It is localized in the Down syndrome critical region of chromosome 21, and is considered to be a strong candidate gene for learning defects associated with Down syndrome. Alternative splicing of this gene generates several transcript variants differing from each other either in the 5' UTR or in the 3' coding region. These variants encode at least five different isoforms. [provided by RefSeq
- Other Designations:
- MNB/DYRK protein kinase,OTTHUMP00000109090,dual specificity YAK1-related kinase,minibrain homolog,mnb protein kinase homolog hp86,protein kinase minibrain homolog,serine/threonine kinase MNB,serine/threonine-specific protein kinase
- Related Disease
