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- Home > Products > Polyclonal Ab > Human > Apoptosis > FOXO3 polyclonal antibody
FOXO3 polyclonal antibody
- 目录号 # : PAB16986
- 访问频率 :
- 尺寸
- 价格
- 库存
- 可得性
- 购物车
- 100 ug
- USD $ 319
- order now, ship in 5 days
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Phone : +886-2-87511888
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- Specification
- Product Description:
- Rabbit polyclonal antibody raised against synthetic peptide of FOXO3.
- Immunogen:
- A synthetic peptide corresponding to residues surrounding S253 of human FOXO3.
- Host:
- Rabbit
- Reactivity:
- Human, Mouse, Rat
- Specificity:
- This antibody detects endogenous levels of total FOXO3 protein.
- Form:
- Liquid
- Recommend Usage:
- Western Blot (1:500-1:1000)
Immunohistochemistry (1:50-1:100)
ELISA (1:20000)
The optimal working dilution should be determined by the end user.
- Storage Buffer:
- In 20 mM PBS, 0.15 M NaCl, pH 7.2 (0.01% sodium azide)
- Storage Instruction:
- Store at 4°C for three months. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.
- Note:
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Publication Reference
- 1.
- Resveratrol preconditioning increases methionine sulfoxide reductases A expression and enhances resistance of human neuroblastoma cells to neurotoxins.
Wu PF, Xie N, Zhang JJ, Guan XL, Zhou J, Long LH, Li YL, Xiong QJ, Zeng JH, Wang F, Chen JG.J Nutr Biochem. 2012 Sep 27. pii: S0955-2863(12)00212-4. doi: 10.1016/j.jnutbio.2012.08.005.
- 2.
- Down-regulation of manganese-superoxide dismutase through phosphorylation of FOXO3a by Akt in explanted vascular smooth muscle cells from old rats.
Li M, Chiu JF, Mossman BT, Fukagawa NK.J Biol Chem. 2006 Dec 29;281(52):40429-39. Epub 2006 Nov 1.
- 3.
- Direct transcriptional regulation of Bim by FoxO3a mediates STI571-induced apoptosis in Bcr-Abl-expressing cells.
Essafi A, Fernandez de Mattos S, Hassen YA, Soeiro I, Mufti GJ, Thomas NS, Medema RH, Lam EW.Oncogene. 2005 Mar 31;24(14):2317-29.
- 4.
- Integration of Smad and forkhead pathways in the control of neuroepithelial and glioblastoma cell proliferation.
Seoane J, Le HV, Shen L, Anderson SA, Massague J.Cell. 2004 Apr 16;117(2):211-23.
- Applications
- Western Blot (Cell lysate)
- Western blot analysis of extracts from NIH/3T3 cells treated with using Serum.
Lane 1 : Using FOXO3 polyclonal antibody (Cat # PAB16986).
Lane 2 : Using the same antibody preincubated with synthesized peptide.
- Entrez GeneID:
- 2309
- Protein Accession#:
- O43524
- Gene Name:
- FOXO3
- Gene Alias:
- AF6q21,DKFZp781A0677,FKHRL1,FKHRL1P2,FOXO2,FOXO3A,MGC12739,MGC31925
- Gene Description:
- forkhead box O3
- Omim ID:
- 602681
- Gene Ontology:
- Hyperlink
- Gene Summary:
- This gene belongs to the forkhead family of transcription factors which are characterized by a distinct forkhead domain. This gene likely functions as a trigger for apoptosis through expression of genes necessary for cell death. Translocation of this gene with the MLL gene is associated with secondary acute leukemia. Alternatively spliced transcript variants encoding the same protein have been observed. [provided by RefSeq
- Other Designations:
- OTTHUMP00000016944,forkhead box O3A,forkhead homolog (rhabdomyosarcoma) like 1,forkhead, Drosophila, homolog of, in rhabdomyosarcoma-like 1
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