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- Home > Products > Polyclonal Ab > Human > Apoptosis > APAF1 polyclonal antibody
APAF1 polyclonal antibody
- 目录号 # : PAB13075
- 访问频率 :
- 尺寸
- 价格
- 库存
- 可得性
- 购物车
- 100 ug
- USD $ 319
- order now, ship in 5 days
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Phone : +886-2-87511888
Fax : +886-2-87511166- 产品会直接装运至客户处。
- Specification
- Product Description:
- Rabbit polyclonal antibody raised against synthetic peptide of APAF1.
- Immunogen:
- A synthetic peptide corresponding to N-terminus of human APAF1.
- Host:
- Rabbit
- Reactivity:
- Human, Mouse, Rat
- Specificity:
- The sequences of the immunogenic peptide are identical between human and mouse.
- Form:
- Liquid
- Recommend Usage:
- Western Blot (1-2 ug/mL)
The optimal working dilution should be determined by the end user.
- Storage Buffer:
- In PBS (0.02% sodium azide)
- Storage Instruction:
- Store at 4°C for three months. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.
- Note:
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Publication Reference
- 1.
- Apaf1 (CED-4 homolog) regulates programmed cell death in mammalian development.
Cecconi F, Alvarez-Bolado G, Meyer BI, Roth KA, Gruss P.Cell. 1998 Sep 18;94(6):727-37.
- 2.
- Bcl-XL interacts with Apaf-1 and inhibits Apaf-1-dependent caspase-9 activation.
Hu Y, Benedict MA, Wu D, Inohara N, Nunez G.Proc Natl Acad Sci U S A. 1998 Apr 14;95(8):4386-91.
- 3.
- Cytochrome c and dATP-dependent formation of Apaf-1/caspase-9 complex initiates an apoptotic protease cascade.
Li P, Nijhawan D, Budihardjo I, Srinivasula SM, Ahmad M, Alnemri ES, Wang X.Cell. 1997 Nov 14;91(4):479-89.
- Entrez GeneID:
- 317
- Protein Accession#:
- AAC51678
- Gene Name:
- APAF1
- Gene Alias:
- CED4,DKFZp781B1145
- Gene Description:
- apoptotic peptidase activating factor 1
- Omim ID:
- 602233
- Gene Ontology:
- Hyperlink
- Gene Summary:
- This gene encodes a cytoplasmic protein that initiates apoptosis. This protein contains several copies of the WD-40 domain, a caspase recruitment domain (CARD), and an ATPase domain (NB-ARC). Upon binding cytochrome c and dATP, this protein forms an oligomeric apoptosome. The apoptosome binds and cleaves caspase 9 preproprotein, releasing its mature, activated form. Activated caspase 9 stimulates the subsequent caspase cascade that commits the cell to apoptosis. Alternative splicing results in several transcript variants encoding different isoforms. [provided by RefSeq
- Other Designations:
- apoptotic protease activating factor 1
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