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- Home > Products > Polyclonal Ab > Phospho-Specific > CREB1 (phospho S121) polyclonal antibody
CREB1 (phospho S121) polyclonal antibody
- 目录号 # : PAB12522
- 访问频率 :
- 尺寸
- 价格
- 库存
- 可得性
- 购物车
- 100 uL
- USD $ 465
- order now, ship in 5 days
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- Specification
- Product Description:
- Rabbit polyclonal antibody raised against synthetic phosphopeptide of CREB1.
- Immunogen:
- Synthetic phosphopeptide corresponding to residues surrounding S121 of human CREB1.
- Host:
- Rabbit
- Reactivity:
- Human, Mouse
- Specificity:
- This antibody is specific to the Ser-121-phosphorylated form of CREB.
- Form:
- Liquid
- Quality Control Testing:
- Antibody Reactive Against Synthetic Peptide.
- Recommend Usage:
- Western Blot (1:500)
Immunoprecipitation (0.5 ug/mL)
The optimal working dilution should be determined by the end user.
- Storage Buffer:
- In Tris (50% glycerol, 0.05% sodium azide)
- Storage Instruction:
- Store at -20°C.
Aliquot to avoid repeated freezing and thawing.
- Note:
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Publication Reference
- 1.
- Identification of carboxyl-terminal MCM3 phosphorylation sites using polyreactive phosphospecific antibodies.
Shi Y, Dodson GE, Mukhopadhyay PS, Shanware NP, Trinh AT, Tibbetts RS.J Biol Chem. 2007 Mar 23;282(12):9236-43. Epub 2007 Jan 23.
- 2.
- Coregulated ataxia telangiectasia-mutated and casein kinase sites modulate cAMP-response element-binding protein-coactivator interactions in response to DNA damage.
Shanware NP, Trinh AT, Williams LM, Tibbetts RS.J Biol Chem. 2007 Mar 2;282(9):6283-91. Epub 2007 Jan 5.
- 3.
- DNA replication stress-induced phosphorylation of cyclic AMP response element-binding protein mediated by ATM.
Dodson GE, Tibbetts RS.J Biol Chem. 2006 Jan 20;281(3):1692-7. Epub 2005 Nov 17.
- 4.
- Ataxia-telangiectasia-mutated (ATM) is a T-antigen kinase that controls SV40 viral replication in vivo.
Shi Y, Dodson GE, Shaikh S, Rundell K, Tibbetts RS.J Biol Chem. 2005 Dec 2;280(48):40195-200. Epub 2005 Oct 11.
- 5.
- Direct regulation of CREB transcriptional activity by ATM in response to genotoxic stress.
Shi Y, Venkataraman SL, Dodson GE, Mabb AM, LeBlanc S, Tibbetts RS.Proc Natl Acad Sci U S A. 2004 Apr 20;101(16):5898-903. Epub 2004 Apr 8.
- Applications
- Western Blot (Cell lysate)
- Western blot analysis of CREB1 (phospho S121) in human HEK 293T cells.
Top panel : probed with CREB1 (phospho S121) polyclonal antibody (Cat # PAB12522). Bottom panel : probed with CREB antibody. Lanes 2 and 4 treated with lambda phosphatase, lanes 3 and 4 treated with 0.2mM H202.
- Entrez GeneID:
- 1385
- Gene Name:
- CREB1
- Gene Alias:
- CREB,MGC9284
- Gene Description:
- cAMP responsive element binding protein 1
- Omim ID:
- 123810
- Gene Ontology:
- Hyperlink
- Gene Summary:
- This gene encodes a transcription factor that is a member of the leucine zipper family of DNA binding proteins. This protein binds as a homodimer to the cAMP-responsive element, an octameric palindrome. The protein is phosphorylated by several protein kinases, and induces transcription of genes in response to hormonal stimulation of the cAMP pathway. Alternate splicing of this gene results in two transcript variants encoding different isoforms. [provided by RefSeq
- Other Designations:
- active transcription factor CREB,cAMP-response element-binding protein-1,transactivator protein
- Related Disease
- Alcoholism
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- Arousal
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- Cognition
- Depressive Disorder, Major
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- Diabetes Mellitus
- Diabetes Mellitus, Type 2
- Disease Models, Animal
- Dominance, Cerebral
