产品浏览
-
- DNA & RNA (46)
- siRNA/Chimera (15364)
- Proteins/Peptides (25865)
- MaxPab® Ab (16217)
- Monoclonal Ab (21396)
- Polyclonal Ab (27483)
- Conjugate Ab/Beads (1328)
- Secondary/Tag Ab (1005)
- Lysates/Slides (9167)
- Ab Pairs/Kits (7698)
- Ab Array Det Kits (1)
- Ab Concentration Kits (1)
- Ab Labeling Kits (40)
- Ab Pairs for ELISA (1352)
- Ab Pairs for IP-WB (2015)
- Ab Pairs for PP (259)
- Ab Pairs for PPI (606)
- Ab Purification Kits (3)
- Assay Kits (521)
- Cell-Based ELISA Kits (708)
- CLIA Kits (44)
- ELISA Kits (2113)
- IHC Kits (6)
- IP & ChIP Kits (20)
- Mutation Detection Kits (3)
- Protein Expression Kits (6)
- Ab & Tissue Arrays (128)
- IHC/Pathology Ab (17916)
- In Situ Hybridization (1056)
- Circulating Tumor Cell (29)
- Systems (4)
- ASR/IVDiagnostics (21)
- Related Product Showcase
- By Research Area
- By Disease
- By Application
 |
 |
Click this icon to add products to compare list. Select up to 10 products.
- Home > Products > Polyclonal Ab > Human > Transcriptions > APEX1 polyclonal antibody
APEX1 polyclonal antibody
- 目录号 # : PAB12487
- 访问频率 :
- 尺寸
- 价格
- 库存
- 可得性
- 购物车
- 100 uL
- USD $ 415
- order now, ship in 5 days
-
-
- 该价格仅在China有效。请选择国家。
- 询问我们任何问题
- 付款信息
信用卡 :
Email : sales@abnova.com
Phone : +886-2-87511888
Fax : +886-2-87511166- 产品会直接装运至客户处。
- Specification
- Product Description:
- Rabbit polyclonal antibody raised against recombinant APEX1.
- Immunogen:
- Recombinant protein corresponding to human APEX1.
- Host:
- Rabbit
- Reactivity:
- Human, Mouse, Rat
- Specificity:
- This antibody is specific to the human APE/ref-1protein.
- Form:
- Liquid
- Quality Control Testing:
- Antibody Reactive Against Recombinant Protein.
- Recommend Usage:
- Immunocytochemistry (1:50-1:200)
Immunofluorescence (1:50-1:200)
Immunoprecipitation (7 ug/mL)
Western Blot (1:1000)
The optimal working dilution should be determined by the end user.
- Storage Buffer:
- In Tris-glycine, 150 mM NaCl (0.05% sodium azide)
- Storage Instruction:
- Store at -20°C or -80°C.
Aliquot to avoid repeated freezing and thawing.
- Note:
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Publication Reference
- 1.
- Effect of hypoxia on the expression of phosphoglycerate kinase and antitumor activity of troxacitabine and gemcitabine in non-small cell lung carcinoma.
Lam W, Bussom S, Cheng YC.Mol Cancer Ther. 2009 Feb;8(2):415-23. Epub 2009 Feb 10.
- 2.
- Down-regulation of apurinic/apyrimidinic endonuclease 1/redox factor-1 expression by soy isoflavones enhances prostate cancer radiotherapy in vitro and in vivo.
Raffoul JJ, Banerjee S, Singh-Gupta V, Knoll ZE, Fite A, Zhang H, Abrams J, Sarkar FH, Hillman GG.Cancer Res. 2007 Mar 1;67(5):2141-9.
- 3.
- Virion-associated uracil DNA glycosylase-2 and apurinic/apyrimidinic endonuclease are involved in the degradation of APOBEC3G-edited nascent HIV-1 DNA.
Yang B, Chen K, Zhang C, Huang S, Zhang H.J Biol Chem. 2007 Apr 20;282(16):11667-75. Epub 2007 Feb 1.
- 4.
- Human monocytes, but not dendritic cells derived from them, are defective in base excision repair and hypersensitive to methylating agents.
Briegert M, Kaina B.Cancer Res. 2007 Jan 1;67(1):26-31.
- 5.
- Expansion of myeloid immune suppressor Gr+CD11b+ cells in tumor-bearing host directly promotes tumor angiogenesis.
Yang L, DeBusk LM, Fukuda K, Fingleton B, Green-Jarvis B, Shyr Y, Matrisian LM, Carbone DP, Lin PC.Cancer Cell. 2004 Oct;6(4):409-21.
- Application Image
- Western Blot (Cell lysate)
- enlarge
- Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
- Immunohistochemistry (Frozen sections)
- Immunocytochemistry
- Immunofluorescence
- Immunoprecipitation
- Entrez GeneID:
- 328
- Protein Accession#:
- P27695
- Gene Name:
- APEX1
- Gene Alias:
- APE,APE-1,APE1,APEN,APEX,APX,HAP1,REF-1,REF1
- Gene Description:
- APEX nuclease (multifunctional DNA repair enzyme) 1
- Omim ID:
- 107748
- Gene Ontology:
- Hyperlink
- Gene Summary:
- Apurinic/apyrimidinic (AP) sites occur frequently in DNA molecules by spontaneous hydrolysis, by DNA damaging agents or by DNA glycosylases that remove specific abnormal bases. AP sites are pre-mutagenic lesions that can prevent normal DNA replication so the cell contains systems to identify and repair such sites. Class II AP endonucleases cleave the phosphodiester backbone 5' to the AP site. This gene encodes the major AP endonuclease in human cells. Splice variants have been found for this gene; all encode the same protein. [provided by RefSeq
- Other Designations:
- AP endonuclease class I,AP lyase,APEX nuclease,DNA-(apurinic or apyrimidinic site) lyase,OTTHUMP00000163988,apurinic/apyrimidinic (abasic) endonuclease,apurinic/apyrimidinic exonuclease,deoxyribonuclease (apurinic or apyrimidinic),multifunctional DNA repa
- Gene Pathway
- Related Disease
- Acute Disease
- Adenocarcinoma
- Adenomatous Polyposis Coli
- Adenomyoma
- Alzheimer Disease
- Alzheimer disease
- Amyotrophic Lateral Sclerosis
- Amyotrophic lateral sclerosis
- Anoxia
- Arsenic Poisoning
- Ataxia telangiectasia
- Biliary Tract Neoplasms
- Brain Neoplasms
- Breast cancer
- Breast Neoplasms
- Carcinoma, Non-Small-Cell Lung
- Carcinoma, Pancreatic Ductal
- Carcinoma, Squamous Cell
- Carcinoma, Transitional Cell
