Rabbit polyclonal antibody raised against synthetic peptide of CASP2.
Immunogen:
A synthetic peptide corresponding to amino acids at C-terminus of human CASP2.
Host:
Rabbit
Reactivity:
Human, Mouse, Rat
Specificity:
Identical to the related rat sequence.
Form:
Lyophilized
Purification:
Affinity purification
Quality Control Testing:
Antibody Reactive Against Synthetic Peptide.
Recommend Usage:
Western Blot (0.5-1 ug/mL) Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) (1-2 ug/mL) The optimal working dilution should be determined by the end user.
Store at -20°C on dry atmosphere. After reconstitution with 200 uL of deionized water and concentration will be 500 ug/mL, store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.
Note:
This product contains sodium azide and thimerosal: POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Defects in regulation of apoptosis in caspase-2-deficient mice. Bergeron L, Perez GI, Macdonald G, Shi L, Sun Y, Jurisicova A, Varmuza S, Latham KE, Flaws JA, Salter JC, Hara H, Moskowitz MA, Li E, Greenberg A, Tilly JL, Yuan J.Genes Dev. 1998 May 1;12(9):1304-14.
This gene encodes a protein which is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce two subunits, large and small, that dimerize to form the active enzyme. The proteolytic cleavage of this protein is induced by a variety of apoptotic stimuli. Alternative splicing of this gene results in multiple transcript variants that encode different isoforms. [provided by RefSeq