Formalin-fixed and paraffin-embedded human skin biopsy (4 µm) from lesion of the early pemphigus vulgaris (without blister formation), stained with C3 monoclonal antibody, clone E28-P (Cat # MAB9757) shows strong positive intraepidermal intercellular immunostaining. Kindly performed and provided by Marian Svajdler, MD and Lucia Frohlichova, MD, from Louis Pasteur University Hospital Department of Pathology, Kosice, Slovak Republic.
Complement component C3 plays a central role in the activation of complement system. Its activation is required for both classical and alternative complement activation pathways. People with C3 deficiency are susceptible to bacterial infection. [provided by RefSeq
acylation-stimulating protein cleavage product,complement component C3