Mouse monoclonal antibody raised against native PSAP.
Immunogen:
Native purified human PSAP.
Host:
Mouse
Reactivity:
Human
Specificity:
This is specific to human prostatic acid phosphatase. It reacts with the glandular epithelium of normal and hyperplastic prostate and with prostate adenocarcinoma. It does not show any cross-reactivity with PSAP from dog, rabbit and rat. Does not react with Dog, Rabbit or Rat.
Form:
Liquid
Isotype:
IgG1, kappa
Recommend Usage:
Immunohistochemistry (1:25-1:100) The optimal working dilution should be determined by the end user.
Storage Buffer:
In buffer containing sodium azide
Storage Instruction:
Store at 4°C. Do not freeze.
Note:
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
This gene encodes a highly conserved glycoprotein which is a precursor for 4 cleavage products: saposins A, B, C, and D. Each domain of the precursor protein is approximately 80 amino acid residues long with nearly identical placement of cysteine residues and glycosylation sites. Saposins A-D localize primarily to the lysosomal compartment where they facilitate the catabolism of glycosphingolipids with short oligosaccharide groups. The precursor protein exists both as a secretory protein and as an integral membrane protein and has neurotrophic activities. Mutations in this gene have been associated with Gaucher disease, Tay-Sachs disease, and metachromatic leukodystrophy. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq
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