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- Home > Products > Monoclonal Ab > Human > Cell Cycle > CDC25A monoclonal antibody, clone PK1-AF12D1
CDC25A monoclonal antibody, clone PK1-AF12D1
- 目录号 # : MAB2742
- 访问频率 :
- 尺寸
- 价格
- 库存
- 可得性
- 购物车
- 100 uL
- USD $ 319
- order now, ship in 5 days
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Phone : +886-2-87511888
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- Specification
- Product Description:
- Mouse monoclonal antibody raised against recombinant CDC25A.
- Immunogen:
- Recombinant protein corresponding to human CDC25A.
- Host:
- Mouse
- Reactivity:
- Human
- Form:
- Liquid
- Purification:
- Ammonium sulfate precipitation
- Concentration:
- 1 mg/mL
- Recommend Usage:
- Western Blot (1:2000)
The optimal working dilution should be determined by the end user.
- Storage Buffer:
- In HEPES, 150 mM NaCl (50% glycerol, 0.01% BSA, 0.03% sodium azide)
- Storage Instruction:
- Store at -20°C.
Aliquot to avoid repeated freezing and thawing.
- Note:
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Publication Reference
- 1.
- Cdc25: mechanisms of checkpoint inhibition and recovery.
Karlsson-Rosenthal C, Millar JB.Trends Cell Biol. 2006 Jun;16(6):285-92. Epub 2006 May 8.
- 2.
- The when and wheres of CDC25 phosphatases.
Boutros R, Dozier C, Ducommun B.Curr Opin Cell Biol. 2006 Apr;18(2):185-91. Epub 2006 Feb 17.
- 3.
- Regulating mammalian checkpoints through Cdc25 inactivation.
Donzelli M, Draetta GF.EMBO Rep. 2003 Jul;4(7):671-7.
- Applications
- Western Blot (Transfected lysate)
- Immunoblot analysis of cell lysates.
Lane 1 : Bosc23 cell lysate.
Lane 2 : Bosc23 cell lysate transfected with Myc/His/Tau (1-441 a. a.).
Lane 3 : Bosc23 cell lysate transfected with Myc/His/CDC25A (291-524E a. a.).
Lane 4 : Bosc23 cell lysate transfected with GFP-Ubiquitin+1.
- Entrez GeneID:
- 993
- Gene Name:
- CDC25A
- Gene Alias:
- CDC25A2
- Gene Description:
- cell division cycle 25 homolog A (S. pombe)
- Omim ID:
- 116947
- Gene Ontology:
- Hyperlink
- Gene Summary:
- CDC25A is a member of the CDC25 family of phosphatases. CDC25A is required for progression from G1 to the S phase of the cell cycle. It activates the cyclin-dependent kinase CDC2 by removing two phosphate groups. CDC25A is specifically degraded in response to DNA damage, which prevents cells with chromosomal abnormalities from progressing through cell division. CDC25A is an oncogene, although its exact role in oncogenesis has not been demonstrated. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq
- Other Designations:
- M-phase inducer phosphatase 1,cell division cycle 25A,dual specificity phosphatase CDC25A
- Interactome
- Gene Pathway
