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- Home > Products > Monoclonal Ab > Human > Signal Transduction > SMAD4 monoclonal antibody, clone IMD-89
SMAD4 monoclonal antibody, clone IMD-89
- 目录号 # : MAB1485
- 访问频率 :
- 尺寸
- 价格
- 库存
- 可得性
- 购物车
- 100 ug
- USD $ 319
- order now, ship in 5 days
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- 该价格仅在China有效。请选择国家。
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Phone : +886-2-87511888
Fax : +886-2-87511166- 产品会直接装运至客户处。
- Specification
- Product Description:
- Mouse monoclonal antibody raised against full length recombinant SMAD4.
- Immunogen:
- Recombinant protein corresponding to full length human SMAD4.
- Host:
- Mouse
- Theoretical MW (kDa):
- 60
- Reactivity:
- Human
- Form:
- Lyophilized
- Purification:
- Affinity purification
- Isotype:
- IgG1
- Quality Control Testing:
- Antibody Reactive Against Recombinant Protein.
- Recommend Usage:
- Western Blot (2-4 ug/mL)
The optimal working dilution should be determined by the end user.
- Storage Buffer:
- Lyophilized from 1.2% sodium acetate (2 mg BSA, 0.01 mg sodium azide)
- Storage Instruction:
- Store at -20°C on dry atmosphere.
After reconstitution with 1 mL of 1.2% sodium acetate or neutral PBS and concentration will be 100 ug/mL, store at -20°C or lower.
Aliquot to avoid repeated freezing and thawing.
- Note:
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Publication Reference
- 1.
- Smad4 signalling in T cells is required for suppression of gastrointestinal cancer.
Kim BG, Li C, Qiao W, Mamura M, Kasprzak B, Anver M, Wolfraim L, Hong S, Mushinski E, Potter M, Kim SJ, Fu XY, Deng C, Letterio JJ.Nature. 2006 Jun 22;441(7096):1015-9.
- 2.
- Mutations in DPC4 (SMAD4) cause juvenile polyposis syndrome, but only account for a minority of cases.
Houlston R, Bevan S, Williams A, Young J, Dunlop M, Rozen P, Eng C, Markie D, Woodford-Richens K, Rodriguez-Bigas MA, Leggett B, Neale K, Phillips R, Sheridan E, Hodgson S, Iwama T, Eccles D, Bodmer W, Tomlinson I.Hum Mol Genet. 1998 Nov;7(12):1907-12.
- 3.
- Mutations in the SMAD4/DPC4 gene in juvenile polyposis.
Howe JR, Roth S, Ringold JC, Summers RW, Jarvinen HJ, Sistonen P, Tomlinson IP, Houlston RS, Bevan S, Mitros FA, Stone EM, Aaltonen LA.Science. 1998 May 15;280(5366):1086-8.
- Application Image
- Western Blot
- Immunocytochemistry
- Entrez GeneID:
- 4089
- Gene Name:
- SMAD4
- Gene Alias:
- DPC4,JIP,MADH4
- Gene Description:
- SMAD family member 4
- Gene Ontology:
- Hyperlink
- Other Designations:
- MAD, mothers against decapentaplegic homolog 4,OTTHUMP00000163548,SMAD, mothers against DPP homolog 4,deleted in pancreatic carcinoma locus 4,mothers against decapentaplegic homolog 4,mothers against decapentaplegic, Drosophila, homolog of, 4
- Interactome
- Related Disease
- Adenocarcinoma
- Adenomatous Polyposis Coli
- Carcinoma, Adenosquamous
- Carcinoma, Pancreatic Ductal
- Carcinoma, Squamous Cell
- Cardiovascular Diseases
- Chromosome Deletion
- Cleft Lip
- Cleft Palate
- Colon cancer
- Colonic Neoplasms
- Colorectal Neoplasms
- Diabetes Mellitus, Type 1
- Diabetes Mellitus, Type 2
- Diabetic Nephropathies
- Disease Models, Animal
- Edema
- Gastrointestinal Neoplasms
- Genetic Predisposition to Disease
