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- Home > Products > Monoclonal Ab > Human > Membrane > Receptor > TLR2 monoclonal antibody, clone 1030A5.138
TLR2 monoclonal antibody, clone 1030A5.138
- 目录号 # : MAB0066
- 访问频率 :
- 尺寸
- 价格
- 库存
- 可得性
- 购物车
- 200 uL
- USD $ 319
- order now, ship in 5 days
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Phone : +886-2-87511888
Fax : +886-2-87511166- 产品会直接装运至客户处。
- Specification
- Product Description:
- Mouse monoclonal antibody raised against full length recombinant TLR2.
- Immunogen:
- Recombinant protein corresponding to extracellular region of human TLR2.
- Host:
- Mouse
- Reactivity:
- Human
- Form:
- Liquid
- Isotype:
- IgG1
- Recommend Usage:
- The optimal working dilution should be determined by the end user.
- Storage Buffer:
- In PBS (0.05% BSA, 0.05% sodium azide)
- Storage Instruction:
- Store at 4°C. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.
- Note:
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Publication Reference
- 1.
- Tissue expression of Toll-like receptors 2 and 4 in sporadic human colorectal cancer.
Nihon-Yanagi Y, Terai K, Murano T, Matsumoto T, Okazumi S.Cancer Immunol Immunother. 2011 Aug 4. [Epub ahead of print]
- 2.
- Inhibition of neutrophil apoptosis by TLR agonists in whole blood: involvement of the phosphoinositide 3-kinase/Akt and NF-kappaB signaling pathways, leading to increased levels of Mcl-1, A1, and phosphorylated Bad.
Francois S, El Benna J, Dang PM, Pedruzzi E, Gougerot-Pocidalo MA, Elbim C.J Immunol. 2005 Mar 15;174(6):3633-42.
- 3.
- Microarray analysis reveals induction of lipoprotein genes in mucoid Pseudomonas aeruginosa: implications for inflammation in cystic fibrosis.
Firoved AM, Ornatowski W, Deretic V.Infect Immun. 2004 Sep;72(9):5012-8.
- 4.
- Soluble forms of Toll-like receptor (TLR)2 capable of modulating TLR2 signaling are present in human plasma and breast milk.
LeBouder E, Rey-Nores JE, Rushmere NK, Grigorov M, Lawn SD, Affolter M, Griffin GE, Ferrara P, Schiffrin EJ, Morgan BP, Labeta MO.J Immunol. 2003 Dec 15;171(12):6680-9.
- 5.
- Glucocorticoids synergistically enhance nontypeable Haemophilus influenzae-induced Toll-like receptor 2 expression via a negative cross-talk with p38 MAP kinase.
Shuto T, Imasato A, Jono H, Sakai A, Xu H, Watanabe T, Rixter DD, Kai H, Andalibi A, Linthicum F, Guan YL, Han J, Cato AC, Lim DJ, Akira S, Li JD.J Biol Chem. 2002 May 10;277(19):17263-70. Epub 2002 Feb 26.
- Applications
- Western Blot (Cell lysate)
- Western blot analysis of TLR2 in 30 ugs of Ramos whole cell lysate. Using TLR2 monoclonal antibody, clone 1030A5.138 (Cat # MAB0066) at 1 : 500.
- Entrez GeneID:
- 7097
- Gene Name:
- TLR2
- Gene Alias:
- CD282,TIL4
- Gene Description:
- toll-like receptor 2
- Gene Ontology:
- Hyperlink
- Gene Summary:
- The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. This gene is expressed most abundantly in peripheral blood leukocytes, and mediates host response to Gram-positive bacteria and yeast via stimulation of NF-kappaB. [provided by RefSeq
- Other Designations:
- toll/interleukin 1 receptor-like 4
- Gene Pathway
- Related Disease
- Acute Disease
- Aggressive Periodontitis
- Agricultural Workers' Diseases
- Amyloidosis
- Arthritis, Reactive
- Arthritis, Rheumatoid
- Aspergillosis
- Aspergillosis, Allergic Bronchopulmonary
- Asthma
- Asthma
- Atherosclerosis
- Atherosclerosis
- Bacteremia
- Bacterial Infections
- Bacteriuria
- Behcet Syndrome
- Birth Weight
- Breast Neoplasms
- Bronchial Hyperreactivity
