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TP53 (Human) Recombinant Protein (P01)
目录号 # : H00007157-P01
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10 ug
USD $ 319
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25 ug
USD $ 485
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Product Description: Human TP53 full-length ORF ( NP_000537.2, 1 a.a. - 393 a.a.) recombinant protein with GST-tag at N-terminal.
Sequence: MEEPQSDPSVEPPLSQETFSDLWKLLPENNVLSPLPSQAMDDLMLSPDDIEQWFTEDPGPDEAPRMPEAAPRVAPAPAAPTPAAPAPAPSWPLSSSVPSQKTYQGSYGFRLGFLHSGTAKSVTCTYSPALNKMFCQLAKTCPVQLWVDSTPPPGTRVRAMAIYKQSQHMTEVVRRCPHHERCSDSDGLAPPQHLIRVEGNLRVEYLDDRNTFRHSVVVPYEPPEVGSDCTTIHYNYMCNSSCMGGMNRRPILTIITLEDSSGNLLGRNSFEVRVCACPGRDRRTEEENLRKKGEPHHELPPGSTKRALPNNTSSSPQPKKKPLDGEYFTLQIRGRERFEMFRELNEALELKDAQAGKEPGGSRAHSSHLKSKKGQSTSRHKKLMFKTEGPDSD
Theoretical MW (kDa): 68.86
Purification: Glutathione Sepharose 4 Fast Flow
Quality Control Testing: 12.5% SDS-PAGE Stained with Coomassie Blue.
Storage Buffer: 50 mM Tris-HCI, 10 mM reduced Glutathione, pH=8.0 in the elution buffer.
Storage Instruction: Store at -80°C. Aliquot to avoid repeated freezing and thawing.
Note: Best use within three months from the date of receipt of this protein.
Enzyme-linked Immunoabsorbent Assay
Western Blot (Recombinant protein)
Enzyme-linked Immunoabsorbent Assay
Western Blot (Recombinant protein)
Gene Alias: FLJ92943,LFS1,TRP53,p53
Gene Description: tumor protein p53
Gene Summary: This gene encodes tumor protein p53, which responds to diverse cellular stresses to regulate target genes that induce cell cycle arrest, apoptosis, senescence, DNA repair, or changes in metabolism. p53 protein is expressed at low level in normal cells and at a high level in a variety of transformed cell lines, where it's believed to contribute to transformation and malignancy. p53 is a DNA-binding protein containing transcription activation, DNA-binding, and oligomerization domains. It is postulated to bind to a p53-binding site and activate expression of downstream genes that inhibit growth and/or invasion, and thus function as a tumor suppressor. Mutants of p53 that frequently occur in a number of different human cancers fail to bind the consensus DNA binding site, and hence cause the loss of tumor suppressor activity. Alterations of this gene occur not only as somatic mutations in human malignancies, but also as germline mutations in some cancer-prone families with Li-Fraumeni syndrome. Multiple p53 variants due to alternative promoters and multiple alternative splicing have been found. These variants encode distinct isoforms, which can regulate p53 transcriptional activity. [provided by RefSeq
Other Designations: p53 antigen,p53 transformation suppressor,p53 tumor suppressor,phosphoprotein p53,transformation-related protein 53
Abortion, Habitual Abortion, Spontaneous Acquired Hyperostosis Syndrome Acute Disease Adenocarcinoma Adenocarcinoma, Clear Cell Adenocarcinoma, Follicular Adenocarcinoma, Mucinous Adenoma Adenoma, Liver Cell Adenomatous Polyposis Coli Adrenal Cortex Neoplasms Albuminuria Alcoholism Alzheimer Disease Alzheimer disease Ameloblastoma Aneuploidy Anoxia
Anus Neoplasms Arsenic Poisoning Arthritis, Psoriatic Arthritis, Rheumatoid Astrocytoma Ataxia telangiectasia Atherosclerosis Autoimmune Diseases Azoospermia Balkan Nephropathy Barrett Esophagus Bipolar Disorder Bone Neoplasms Brain Infarction Brain Injuries Brain Ischemia Brain Neoplasms Breast cancer Breast Neoplasms Carcinoma Carcinoma in Situ Carcinoma, Adenosquamous Carcinoma, Basal Cell Carcinoma, Ductal Carcinoma, Ductal, Breast Carcinoma, Endometrioid Carcinoma, Hepatocellular Carcinoma, Intraductal, Noninfiltrating Carcinoma, Large Cell Carcinoma, Lobular Carcinoma, Non-Small-Cell Lung Carcinoma, Pancreatic Ductal Carcinoma, Papillary Carcinoma, Renal Cell Carcinoma, Squamous Cell Carcinoma, Transitional Cell Cardiovascular Diseases Carotid Artery Diseases Carotid Artery Thrombosis Cell Transformation, Neoplastic Cerebellar Neoplasms Cerebral Infarction Cervical Intraepithelial Neoplasia Chagas Disease Cholecystitis Choriocarcinoma Choroid Plexus Neoplasms Chromosomal Instability Chromosome Aberrations Chromosome Deletion Chronic Disease Cicatrix, Hypertrophic Cocarcinogenesis Cognition Disorders Colitis, Ulcerative Colon cancer Colonic Neoplasms Colorectal Neoplasms Colorectal Neoplasms, Hereditary Nonpolyposis Condylomata Acuminata Conjunctival Neoplasms Constriction, Pathologic Coronary Artery Disease Coronary Disease Coronary Restenosis Craniocerebral Trauma Crohn Disease Crohn's disease Cystadenocarcinoma, Serous Delayed Graft Function Depressive Disorder, Major Diabetes Mellitus Diabetes Mellitus, Type 1 Diabetes Mellitus, Type 2 Diabetic Nephropathies Digestive System Neoplasms Disease Progression Disease Susceptibility DNA Damage Down Syndrome Duodenal Ulcer Edema Ehlers-Danlos Syndrome Endometrial Hyperplasia Endometrial Neoplasms Endometriosis Epidermodysplasia Verruciformis Epstein-Barr Virus Infections Esophageal Neoplasms Fallopian Tube Neoplasms Gallbladder Neoplasms Ganglioglioma Gastritis Gastritis, Atrophic Gastroesophageal Reflux Gastrointestinal Neoplasms Gastrointestinal Stromal Tumors Genetic Diseases, Inborn Genetic Predisposition to Disease Genital Neoplasms, Female Genomic Instability Glaucoma Glaucoma, Open-Angle Glioblastoma Glioma Graft Occlusion, Vascular Graves Disease Hashimoto Disease Head and Neck Neoplasms Helicobacter Infections Hematologic Diseases Hepatitis B Hepatitis B, Chronic Hepatitis C Hepatitis C, Chronic Herpes Simplex HIV Infections Hodgkin Disease Hydatidiform Mole Hypopharyngeal Neoplasms Hypotension Infertility, Female Infertility, Male Inflammation Inflammatory Bowel Diseases Intestinal Neoplasms Intracranial Thrombosis Keloid Keratosis Kidney Failure, Chronic Kidney Neoplasms Laryngeal Neoplasms Leber hereditary optic neuropathy Leiomyoma Leukemia Leukemia, B-Cell, Chronic Leukemia, chronic myeloid Leukemia, Lymphocytic, Chronic Leukemia, Lymphocytic, Chronic, B-Cell Leukemia, Myeloid Leukemia, Myeloid, Acute Leukemia, Myeloid, Chronic Leukoplakia Leukoplakia, Oral Lichen Planus, Oral Li-Fraumeni Syndrome Lissencephaly Liver Cirrhosis Liver Neoplasms Low Tension Glaucoma Lung Neoplasms Lupus Erythematosus, Systemic Lupus Nephritis Lymphatic Metastasis Lymphoma Lymphoma, B-Cell Lymphoma, B-Cell, Marginal Zone Lymphoma, Follicular Lymphoma, Large B-Cell, Diffuse Lymphoma, Large-Cell Lymphoma, Mantle-Cell Lymphoma, Non-Hodgkin Lymphoproliferative Disorders Malignant melanoma Medulloblastoma Melanoma Meningeal Neoplasms Meningioma Mental Retardation Metaplasia Microsatellite Instability Mouth Neoplasms Multiple Myeloma Multiple Sclerosis Myelodysplastic Syndromes Nasopharyngeal Neoplasms Neoplasm Invasiveness Neoplasm Metastasis Neoplasm Recurrence, Local Neoplasms Neoplasms, Basal Cell Neoplasms, Glandular and Epithelial Neoplasms, Hormone-Dependent Neoplasms, Radiation-Induced Neoplasms, Second Primary Neoplasms, Squamous Cell Nerve Sheath Neoplasms Neural Tube Defects Neurilemmoma Neuroectodermal Tumors, Primitive Neurofibroma Neurofibromatosis Neurofibromatosis 2 Neuroma, Acoustic Neuropsychological Tests Neutropenia Nijmegen Breakage Syndrome Nose Neoplasms Obesity Obesity Occupational Diseases Ocular Hypertension Oligodendroglioma Oligospermia Optic Atrophy, Hereditary, Leber Oral Submucous Fibrosis Oropharyngeal Neoplasms Osteoarthritis Osteosarcoma Ovarian cancer Ovarian Neoplasms Pancreatic cancer Pancreatic Neoplasms Papilloma, Choroid Plexus Papillomavirus Infections Pemphigus Penile Neoplasms Peptic Ulcer Peritoneal Neoplasms Pharyngeal Neoplasms Postoperative Complications Precancerous Conditions Prostate cancer Prostatic Hyperplasia Prostatic Intraepithelial Neoplasia Prostatic Neoplasms Psoriasis Pterygium Pulmonary Disease, Chronic Obstructive Pulmonary Fibrosis Radiation Injuries Radiodermatitis Rectal Neoplasms Recurrence Roseolovirus Infections Sarcoma Sarcoma, Kaposi Schizophrenia Schizophrenia Skin Diseases Skin Neoplasms Small Cell Lung Carcinoma Spinal Dysraphism Stomach Neoplasms Stomach Ulcer Subarachnoid Hemorrhage Substance-Related Disorders Sunburn The p53 tumor suppressor protein Thyroid Diseases Thyroid Neoplasms Thyroiditis, Autoimmune Tobacco Use Disorder Tongue Neoplasms Tumor Virus Infections Uremia Urinary Bladder Neoplasms Urologic Diseases Uterine Cervical Diseases Uterine Cervical Dysplasia Uterine Cervical Neoplasms Uterine Neoplasms Waldenstrom Macroglobulinemia Wegener Granulomatosis Werner syndrome
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