Plastins are a family of actin-binding proteins that are conserved throughout eukaryote evolution and expressed in most tissues of higher eukaryotes. In humans, two ubiquitous plastin isoforms (L and T) have been identified. Plastin 1 (otherwise known as Fimbrin) is a third distinct plastin isoform which is specifically expressed at high levels in the small intestine. The L isoform is expressed only in hemopoietic cell lineages, while the T isoform has been found in all other normal cells of solid tissues that have replicative potential (fibroblasts, endothelial cells, epithelial cells, melanocytes, etc.). However, L-plastin has been found in many types of malignant human cells of non-hemopoietic origin suggesting that its expression is induced accompanying tumorigenesis in solid tissues. [provided by RefSeq
Other Designations:
L-plastin,L-plastin (Lymphocyte cytosolic protein 1) (LCP-1) (LC64P),Lymphocyte cytosolic protein-1 (plasmin),OTTHUMP00000018362,bA139H14.1 (lymphocyte cytosolic protein 1 (L-plastin)),plastin 2