Immunoprecipitation of KCNE1 transfected lysate using anti-KCNE1 monoclonal antibody and Protein A Magnetic Bead (U0007), and immunoblotted with KCNE1 MaxPab rabbit polyclonal antibody.
The product of this gene belongs to the potassium channel KCNE family. Potassium ion channels are essential to many cellular functions and show a high degree of diversity, varying in their electrophysiologic and pharmacologic properties. This gene encodes a transmembrane protein known to associate with the product of the KVLQT1 gene to form the delayed rectifier potassium channel. Mutation in this gene are associated with both Jervell and Lange-Nielsen and Romano-Ward forms of long-QT syndrome. Alternatively spliced transcript variants encoding the same protein have been identified. [provided by RefSeq