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IL4R monoclonal antibody (M01A), clone 1D3
目录号 # : H00003566-M01A
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200 uL
USD $ 319
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Product Description: Mouse monoclonal antibody raised against a partial recombinant IL4R.
Immunogen: IL4R (NP_000409, 26 a.a. ~ 135 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Sequence: MKVLQEPTCVSDYMSISTCEWKMNGPTNCSTELRLLYQLVFLLSEAHTCIPENNGGAGCVCHLLMDDVVSADNYTLDLWAGQQLLWKGSFKPSEHVKPRAPGNLTVHTNV
Quality Control Testing: Antibody Reactive Against Recombinant Protein.
Storage Buffer: In ascites fluid
Storage Instruction: Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.
Gene Description: interleukin 4 receptor
Gene Summary: This gene encodes the alpha chain of the interleukin-4 receptor, a type I transmembrane protein that can bind interleukin 4 and interleukin 13 to regulate IgE production. The encoded protein also can bind interleukin 4 to promote differentiation of Th2 cells. A soluble form of the encoded protein can be produced by an alternate splice variant or by proteolysis of the membrane-bound protein, and this soluble form can inhibit IL4-mediated cell proliferation and IL5 upregulation by T-cells. Allelic variations in this gene have been associated with atopy, a condition that can manifest itself as allergic rhinitis, sinusitus, asthma, or eczema. Two transcript variants encoding different isoforms, a membrane-bound and a soluble form, have been found for this gene. [provided by RefSeq
Other Designations: OTTHUMP00000122506,interleukin 4 receptor alpha chain,interleukin-4 receptor alpha chain
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