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- Home > Products > Proteins/Peptides > Human > Partial-length > Cell Cycle > BIN1 (Human) Recombinant Protein (Q01)
BIN1 (Human) Recombinant Protein (Q01)
- 目录号 # : H00000274-Q01
- 访问频率 :
- 尺寸
- 价格
- 库存
- 可得性
- 购物车
- 10 ug
- USD $ 319
- order now, ship next day
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- 25 ug
- USD $ 485
- order now, ship next day
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- Specification
- Product Description:
- Human BIN1 partial ORF ( NP_004296, 355 a.a. - 454 a.a.) recombinant protein with GST-tag at N-terminal.
- Sequence:
- VVETFPATVNGTVEGGSGAGRLDLPPGFMFKVQAQHDYTATDTDELQLKAGDVVLVIPFQNPEEQDEGWLMGVKESDWNQHKELEKCRGVFPENFTERVP
- Theoretical MW (kDa):
- 36.74
- Preparation Method:
- in vitro wheat germ expression system
- Purification:
- Glutathione Sepharose 4 Fast Flow
- Quality Control Testing:
- 12.5% SDS-PAGE Stained with Coomassie Blue.
- Storage Buffer:
- 50 mM Tris-HCI, 10 mM reduced Glutathione, pH=8.0 in the elution buffer.
- Storage Instruction:
- Store at -80°C. Aliquot to avoid repeated freezing and thawing.
- Note:
- Best use within three months from the date of receipt of this protein.
- MSDS:
Download
- Application Image
- Enzyme-linked Immunoabsorbent Assay
- Western Blot (Recombinant protein)
- Antibody Production
- Protein Array
- Entrez GeneID:
- 274
- GeneBank Accession#:
- NM_004305
- Protein Accession#:
- NP_004296
- Gene Name:
- BIN1
- Gene Alias:
- AMPH2,AMPHL,DKFZp547F068,MGC10367,SH3P9
- Gene Description:
- bridging integrator 1
- Gene Ontology:
- Hyperlink
- Gene Summary:
- This gene encodes several isoforms of a nucleocytoplasmic adaptor protein, one of which was initially identified as a MYC-interacting protein with features of a tumor suppressor. Isoforms that are expressed in the central nervous system may be involved in synaptic vesicle endocytosis and may interact with dynanim, synaptojanin, endophilin, and clathrin. Isoforms that are expressed in muscle and ubiquitously expressed isoforms localize to the cytoplasm and nucleus and activate a caspase-independent apoptotic process. Studies in mouse suggest that this gene plays an important role in cardiac muscle development. Alternate splicing of the gene results in ten transcript variants encoding different isoforms. Aberrant splice variants expressed in tumor cell lines have also been described. [provided by RefSeq
- Other Designations:
- OTTHUMP00000162179,OTTHUMP00000162183,amphiphysin II,amphiphysin-like,box dependant MYC interacting protein 1
