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- Home > Products > Ab Pairs/Kits > Ab Pairs for PP > PDGFRB(phospho Y740) & PDGFRB Protein Phosphorylation Antibody Pair
PDGFRB(phospho Y740) & PDGFRB Protein Phosphorylation Antibody Pair
- 目录号 # : DP0005
- 访问频率 :
- 尺寸
- 价格
- 库存
- 可得性
- 购物车
- 1 Set
- USD $ 589
- order now, ship in 2 weeks
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- Specification
- Product Description:
- This protein phosphorylation antibody pair set comes with two antibodies, one against the PDGFRB protein, and the other against the specific Y740 phosphorylated site of PDGFRB for use in in situ Proximity Ligation Assay. See Publication Reference below.
- Reactivity:
- Human
- Quality Control Testing:
- Dual recognition immunofluorescence result.
Representative image of Proximity Ligation Assay of protein phosphorylation. HeLa cells were stained with dual recognition antibody pair set, rabbit polyclonal antibody 1:1200 and mouse monoclonal antibody 1:50. Each red dot represents one single phosphorylated protein. The images were analyzed using an optimized freeware (BlobFinder) download from The Centre for Image Analysis at Uppsala University.
- Supplied Product:
- Antibody pair set content:
1. Phospho-PDGFRB Y740 rabbit polyclonal antibody (20 ul)
2. PDGFRB mouse monoclonal antibody (40 ug)
In 1x PBS, pH 7.2
*Reagents are sufficient for at least 30-50 assays using recommended protocols.
- Storage Instruction:
- Store reagents of the antibody pair set at -20°C or lower. Please aliquot to avoid repeated freeze thaw cycle. Reagents should be returned to -20°C storage immediately after use.
- 1.
- In situ detection of phosphorylated platelet-derived growth factor receptor beta using a generalized proximity ligation method.
Jarvius M, Paulsson J, Weibrecht I, Leuchowius KJ, Andersson AC, Wahlby C, Gullberg M,Botling J, Sjoblom T, Markova B, Ostman A, Landegren U, Soderberg O.
Mol Cell Proteomics. 2007 Sep;6(9):1500-9. Epub 2007 Jun 12.
- 2.
- Direct observation of individual endogenous protein complexes in situ by proximity ligation.
Soderberg O, Gullberg M, Jarvius M , Ridderstrale K, Leuchowius KJ, Jarvius J, Wester K, Hydbring P, Bahram F, Larsson LG, and Landegren U.
Nat Methods. 2006 Dec;3(12):995-1000. Epub 2006 Oct 29.
- 3.
- Cytokine detection by antibody-based proximity ligation.
Gullberg M, Gustafsdottir SM, Schallmeiner E, Jarvius J, Bjarnegard M, Betsholtz C, Landegren U, and Fredriksson S.
Proc Natl Acad Sci U S A. 2004 Jun 1;101(22):8420-4. Epub 2004 May 21.
- 4.
- Protein detection using proximity-dependent DNA ligation assays.
Fredriksson S, GullbergM, Jarvius J, Olsson C, Pietras K, Gustafsdottir SM, Ostman A, and Landegren U.
Nat Biotechnol. 2002 May;20(5):473-7.
- 5.
- Highly specific detection of phosphorylated proteins by Duolink
Mats Gullberg and Ann-Catrin Andersson
Nature Methods 6. 2009
- Application Image
- In situ Proximity Ligation Assay (Cell)
- Entrez GeneID:
- 5159
- Gene Name:
- PDGFRB
- Gene Alias:
- CD140B,JTK12,PDGF-R-beta,PDGFR,PDGFR1
- Gene Description:
- platelet-derived growth factor receptor, beta polypeptide
- Gene Ontology:
- Hyperlink
- Gene Summary:
- This gene encodes a cell surface tyrosine kinase receptor for members of the platelet-derived growth factor family. These growth factors are mitogens for cells of mesenchymal origin. The identity of the growth factor bound to a receptor monomer determines whether the functional receptor is a homodimer or a heterodimer, composed of both platelet-derived growth factor receptor alpha and beta polypeptides. This gene is flanked on chromosome 5 by the genes for granulocyte-macrophage colony-stimulating factor and macrophage-colony stimulating factor receptor; all three genes may be implicated in the 5-q syndrome. A translocation between chromosomes 5 and 12, that fuses this gene to that of the translocation, ETV6, leukemia gene, results in chronic myeloproliferative disorder with eosinophilia. [provided by RefSeq
- Other Designations:
- beta platelet-derived growth factor receptor,platelet-derived growth factor receptor beta,soluble PDGFRb variant 1
- Interactome
- Related Disease
- Acute Disease
- Adenocarcinoma
- Alzheimer Disease
- Alzheimer disease
- Cardiovascular Diseases
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- Diabetes Mellitus, Type 2
- Disease Models, Animal
- Edema
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- Genetic Predisposition to Disease
- Hyperparathyroidism, Secondary
- Kidney Failure, Chronic
- Leukemia, Myeloid
- Metabolic Syndrome X
- Neoplasms
- Osteoporosis
- Ovarian Neoplasms
- Schizophrenia
