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- Home > Products > Polyclonal Ab > Human > Signal Transduction > APH1A polyclonal antibody
APH1A polyclonal antibody
- 目录号 # : PAB8483
- 访问频率 :
- 尺寸
- 价格
- 库存
- 可得性
- 购物车
- 25 ug
- ..........
- order now, ship in 5 days
- Inquiry
- 付款信息
信用卡 :
Email : sales@abnova.com
Phone : +886-2-87511888
Fax : +886-2-87511166- 产品会直接装运至客户处。
- Specification
- Product Description:
- Rabbit polyclonal antibody raised against synthetic peptide of APH1A.
- Immunogen:
- A synthetic peptide corresponding to human APH1A.
- Host:
- Rabbit
- Reactivity:
- Human
- Form:
- Liquid
- Quality Control Testing:
- Antibody Reactive Against Synthetic Peptide.
- Recommend Usage:
- Western Blot (3-10 ug/mL)
The optimal working dilution should be determined by the end user.
- Storage Buffer:
- In PBS (0.1% proclin, 2.0% Block Ace)
- Storage Instruction:
- Store at -20°C.
Aliquot to avoid repeated freezing and thawing.
- Publication Reference
- 1.
- The role of presenilin cofactors in the gamma-secretase complex.
Takasugi N, Tomita T, Hayashi I, Tsuruoka M, Niimura M, Takahashi Y, Thinakaran G, Iwatsubo T.Nature. 2003 Mar 27;422(6930):438-41. Epub 2003 Mar 16.
- 2.
- Mammalian APH-1 interacts with presenilin and nicastrin and is required for intramembrane proteolysis of amyloid-beta precursor protein and Notch.
Lee SF, Shah S, Li H, Yu C, Han W, Yu G.J Biol Chem. 2002 Nov 22;277(47):45013-9. Epub 2002 Sep 23.
- 3.
- Gamma-secretase-mediated proteolysis in cell-surface-receptor signalling.
Fortini ME.Nat Rev Mol Cell Biol. 2002 Sep;3(9):673-84.
- 4.
- aph-1 and pen-2 are required for Notch pathway signaling, gamma-secretase cleavage of betaAPP, and presenilin protein accumulation.
Francis R, McGrath G, Zhang J, Ruddy DA, Sym M, Apfeld J, Nicoll M, Maxwell M, Hai B, Ellis MC, Parks AL, Xu W, Li J, Gurney M, Myers RL, Himes CS, Hiebsch R, Ruble C, Nye JS, Curtis D.Dev Cell. 2002 Jul;3(1):85-97.
- 5.
- APH-1 is a multipass membrane protein essential for the Notch signaling pathway in Caenorhabditis elegans embryos.
Goutte C, Tsunozaki M, Hale VA, Priess JR.Proc Natl Acad Sci U S A. 2002 Jan 22;99(2):775-9. Epub 2002 Jan 15.
- Entrez GeneID:
- 51107
- Gene Name:
- APH1A
- Gene Alias:
- 6530402N02Rik,APH-1A,CGI-78
- Gene Description:
- anterior pharynx defective 1 homolog A (C. elegans)
- Omim ID:
- 607629
- Gene Ontology:
- Hyperlink
- Gene Summary:
- APH1 is a multipass transmembrane protein that interacts with presenilin (see PSEN1; MIM 104311) and nicastrin (APH2; MIM 605254) as a functional component of the gamma-secretase complex. The gamma-secretase complex is required for the intramembrane proteolysis of a number of membrane proteins, including the amyloid-beta precursor protein (APP; MIM 104760) and Notch (MIM 190198).[supplied by OMIM
- Other Designations:
- OTTHUMP00000014528,OTTHUMP00000014529,anterior pharynx defective 1 homolog A
- Gene Pathway
