Rabbit polyclonal antibody raised against synthetic peptide of Beta amyloid.
Immunogen:
A synthetic peptide (conjugated with KLH) corresponding to amino acids 1-42 of human Amyloid-beta.
Sequence:
DAEFRHDSGYEVHHQKLVFFAEDVGSNKGAIIGLMVGGVVIA
Host:
Rabbit
Reactivity:
Human
Specificity:
This antibody can detect Abeta (1-42), Abeta (1-28) Abeta (1-20) and Abeta (1-17). This product exhibits a low reactivity to monomeric Abeta (1-42).
Form:
Lyophilized
Recommend Usage:
ELISA (1:3000) Dot Blot (1:1000) The optimal working dilution should be determined by the end user.
Storage Buffer:
Lyophilized from serum
Storage Instruction:
Store at -20°C on dry atmosphere. After reconstitution with sterile water, store at -20°C. Aliquot to avoid repeated freezing and thawing.
Applications
ELISA
Dot Blot (Peptide)
Dot blot of Beta amyloid polyclonal antibody (Cat # PAB13587) at a 1 : 1000 dilution. The antibody can detect Beta amyloid (1-42), Beta amyloid (1-28), Beta amyloid (1-20) and Beta amyloid (1-17).
This gene encodes a cell surface receptor and transmembrane precursor protein that is cleaved by secretases to form a number of peptides. Some of these peptides are secreted and can bind to the acetyltransferase complex APBB1/TIP60 to promote transcriptional activation, while others form the protein basis of the amyloid plaques found in the brains of patients with Alzheimer disease. Mutations in this gene have been implicated in autosomal dominant Alzheimer disease and cerebroarterial amyloidosis (cerebral amyloid angiopathy). Multiple transcript variants encoding several different isoforms have been found for this gene. [provided by RefSeq