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BRCA1 monoclonal antibody   

  • 目录号 # : MAB6119
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  • 100 uL
  • USD $ 515
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  • Specification
  • Product Description:
  • Mouse monoclonal antibody raised against partial recombinant BRCA1.
  • Immunogen:
  • Recombinant GST fusion protein corresponding to amino acids 762-1315 of human BRCA1.
  • Host:
  • Mouse
  • Reactivity:
  • Human
  • Specificity:
  • This antibody recognizes full-length BRCA1, a 220 kD nuclear phosphoprotein, and does not recognize the Deltaexon 11 splice variant.
  • Form:
  • Liquid
  • Isotype:
  • IgG1, kappa
  • Recommend Usage:
  • Western Blot (1-10 ug/mL)
    Immunoprecipitation (1-10 ug/mL)
    Immunohistochemistry (1-10 ug/mL)
    The optimal working dilution should be determined by the end user.
  • Storage Buffer:
  • In PBS, pH 7.4
  • Storage Instruction:
  • Store at -80°C.
    Aliquot to avoid repeated freezing and thawing.
  • Publication Reference
  • Applications
  • Western Blot
  • Immunohistochemistry
  • Immunoprecipitation
  • Application Image
  • Western Blot
  • Immunohistochemistry
  • Immunoprecipitation
  • Gene Information
  • Entrez GeneID:
  • 672
  • Gene Name:
  • BRCA1
  • Gene Alias:
  • BRCAI,BRCC1,IRIS,PSCP,RNF53
  • Gene Description:
  • breast cancer 1, early onset
  • Gene Summary:
  • This gene encodes a nuclear phosphoprotein that plays a role in maintaining genomic stability, and it also acts as a tumor suppressor. The encoded protein combines with other tumor suppressors, DNA damage sensors, and signal transducers to form a large multi-subunit protein complex known as the BRCA1-associated genome surveillance complex (BASC). This gene product associates with RNA polymerase II, and through the C-terminal domain, also interacts with histone deacetylase complexes. This protein thus plays a role in transcription, DNA repair of double-stranded breaks, and recombination. Mutations in this gene are responsible for approximately 40% of inherited breast cancers and more than 80% of inherited breast and ovarian cancers. Alternative splicing plays a role in modulating the subcellular localization and physiological function of this gene. Many alternatively spliced transcript variants, some of which are disease-associated mutations, have been described for this gene, but the full-length natures of only some of these variants has been described. A related pseudogene, which is also located on chromosome 17, has been identified. [provided by RefSeq
  • Other Designations:
  • BRCA1/BRCA2-containing complex, subunit 1,breast and ovarian cancer susceptibility protein 1
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