Mouse monoclonal antibody raised against recombinant MAP3K7IP2.
Immunogen:
Recombinant protein corresponding to human MAP3K7IP2.
Host:
Mouse
Theoretical MW (kDa):
80
Reactivity:
Human
Form:
Liquid
Recommend Usage:
ELISA (1:10000) Western Blot (1:500-1:2000) Flow cytometry (1:200-1:400) The optimal working dilution should be determined by the end user.
Storage Buffer:
In ascites (0.03% sodium azide)
Storage Instruction:
Store at 4°C. For long term storage store at -20°C. Aliquot to avoid repeated freezing and thawing.
Note:
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Applications
Western Blot (Transfected lysate)
Western blot analysis using MAP3K7IP2 monoclonal antobody, clone 3B5 (Cat # MAB10330) against HEK293 (1) and MAP3K7IP2-hIgGFc transfected HEK293 (2) cell lysate.
ELISA
Flow Cytometry
Flow cytometric analysis of HL-60 cells using MAP3K7IP2 monoclonal antobody, clone 3B5 (Cat # MAB10330) (green) and negative control (purple).
The protein encoded by this gene is an activator of MAP3K7/TAK1, which is required for for the IL-1 induced activation of nuclear factor kappaB and MAPK8/JNK. This protein forms a kinase complex with TRAF6, MAP3K7 and TAB1, thus serves as an adaptor linking MAP3K7 and TRAF6. This protein, TAB1, and MAP3K7 also participate in the signal transduction induced by TNFSF11/RANKl through the activation of the receptor activator of NF-kappB (TNFRSF11A/RANK), which may regulate the development and function of osteoclasts. [provided by RefSeq
Other Designations:
OTTHUMP00000017388,OTTHUMP00000040125,TAK1-binding protein 2
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