This gene encodes a zinc-dependent aminopeptidase that cleaves vasopressin, oxytocin, lys-bradykinin, met-enkephalin, dynorphin A and other peptide hormones. The protein can be secreted in maternal serum, reside in intracellular vesicles with the insulin-responsive glucose transporter GLUT4, or form a type II integral membrane glycoprotein. The protein catalyzes the final step in the conversion of angiotensinogen to angiotensin IV (AT4) and is also a receptor for AT4. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq
Other Designations:
AT (4) receptor,OTTHUMP00000196800,angiotensin IV receptor,insulin-regulated aminopeptidase,insulin-responsive aminopeptidase,otase,oxytocinase,placental leucine aminopeptidase,vasopressinase
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