BAD (Bcl-2 antagonist of cell death) belongs to the pro-apoptotic BH3-only subfamily of Bcl- 2 proteins. Physiological activity of BAD is highly controlled by phosphorylation. To further analyze the regulation of BAD function, the authors (Polzien L, Baljuls A, Albrecht M, Hekman M, Rapp UR) investigated the role of recently identified phosphorylation sites on BAD-mediated apoptosis.
Cohesinopathies are human developmental disorders caused by inherited defects in cellular components controlling the process of sister chromatid cohesion. This cohesion mechanism takes care of keeping the sister chromatids close together from the stage of DNA replication up until mitosis. Two syndromes were described so far in the group of cohesinopathes: Roberts syndrome and Cornelia de Lange syndrome. In Van der Lelij research, a third cohesinopathy is added to this group: The Warsaw Breakage syndrome, caused by mutations in DDX11/ChlR1.