CDH1 polyclonal antibody
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More Files
- More Functions
Western Blot (Cell lysate)
Western blot of human A-431 cells that were probed with CDH1 polyclonal antibody (Cat # PAB7893) at 1:250 (lane 1), 1:1000 (lane 2), and 1:4000 (lane 3).
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Specification
Product Description
Rabbit polyclonal antibody raised against synthetic peptide of CDH1.
Immunogen
A synthetic peptide corresponding to C-terminus of human CDH1.
Host
Rabbit
Reactivity
Human, Mouse, Rat
Specificity
This sequence is conserved in rat and mouse E-cadherin, and has low homology to other cadherin family members.
Form
Liquid
Quality Control Testing
Antibody Reactive Against Synthetic Peptide.
Recommend Usage
ELISA (1:2000)
Western Blot (1:500)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS (50% glycerol, 1 mg/mL BSA, 0.05% sodium azide)
Storage Instruction
Store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Cell lysate)
Western blot of human A-431 cells that were probed with CDH1 polyclonal antibody (Cat # PAB7893) at 1:250 (lane 1), 1:1000 (lane 2), and 1:4000 (lane 3).Enzyme-linked Immunoabsorbent Assay
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Gene Info — CDH1
Entrez GeneID
999Protein Accession#
P12830Gene Name
CDH1
Gene Alias
Arc-1, CD324, CDHE, ECAD, LCAM, UVO
Gene Description
cadherin 1, type 1, E-cadherin (epithelial)
Gene Ontology
HyperlinkGene Summary
This gene is a classical cadherin from the cadherin superfamily. The encoded protein is a calcium dependent cell-cell adhesion glycoprotein comprised of five extracellular cadherin repeats, a transmembrane region and a highly conserved cytoplasmic tail. Mutations in this gene are correlated with gastric, breast, colorectal, thyroid and ovarian cancer. Loss of function is thought to contribute to progression in cancer by increasing proliferation, invasion, and/or metastasis. The ectodomain of this protein mediates bacterial adhesion to mammalian cells and the cytoplasmic domain is required for internalization. Identified transcript variants arise from mutation at consensus splice sites. [provided by RefSeq
Other Designations
cadherin 1, E-cadherin (epithelial)|cadherin 1, type 1|calcium-dependent adhesion protein, epithelial|cell-CAM 120/80|uvomorulin
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Interactome
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Pathway
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Disease
- Adenocarcinoma
- Asthma
- Breast cancer
- Breast Neoplasms
- Bronchiolitis
- Carcinoma
- Cleft Lip
- Cleft Palate
- Colitis
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Publication Reference
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Involvement of Src family kinases in N-cadherin phosphorylation and beta-catenin dissociation during transendothelial migration of melanoma cells.
Qi J, Wang J, Romanyuk O, Siu CH.
Molecular Biology of the Cell 2005 Dec; 17(3):1261.
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Interaction of the adaptor protein Shc and the adhesion molecule cadherin.
Xu Y, Guo DF, Davidson M, Inagami T, Carpenter G.
The Journal of Biological Chemistry 1997 May; 272(21):13463.
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The cadherins: cell-cell adhesion molecules controlling animal morphogenesis.
Takeichi M.
Development 1988 Apr; 102(4):639.
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Involvement of Src family kinases in N-cadherin phosphorylation and beta-catenin dissociation during transendothelial migration of melanoma cells.
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