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Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)

Immunofluorescence

Entrez GeneID

Protein Accession#

Gene Name

AKT1

Gene Alias

AKT, MGC99656, PKB, PKB-ALPHA, PRKBA, RAC, RAC-ALPHA

Gene Description

v-akt murine thymoma viral oncogene homolog 1

Omim ID

Gene Ontology

Gene Summary

The serine-threonine protein kinase encoded by the AKT1 gene is catalytically inactive in serum-starved primary and immortalized fibroblasts. AKT1 and the related AKT2 are activated by platelet-derived growth factor. The activation is rapid and specific, and it is abrogated by mutations in the pleckstrin homology domain of AKT1. It was shown that the activation occurs through phosphatidylinositol 3-kinase. In the developing nervous system AKT is a critical mediator of growth factor-induced neuronal survival. Survival factors can suppress apoptosis in a transcription-independent manner by activating the serine/threonine kinase AKT1, which then phosphorylates and inactivates components of the apoptotic machinery. Multiple alternatively spliced transcript variants have been found for this gene. [provided by RefSeq

Other Designations

RAC-alpha serine/threonine-protein kinase|murine thymoma viral (v-akt) oncogene homolog-1|protein kinase B|rac protein kinase alpha

Entrez GeneID

Protein Accession#

Gene Name

AKT2

Gene Alias

PKBB, PKBBETA, PRKBB, RAC-BETA

Gene Description

v-akt murine thymoma viral oncogene homolog 2

Omim ID

Gene Ontology

Gene Summary

This gene is a putative oncogene encoding a protein belonging to a subfamily of serine/threonine kinases containing SH2-like (Src homology 2-like) domains. The gene was shown to be amplified and overexpressed in 2 of 8 ovarian carcinoma cell lines and 2 of 15 primary ovarian tumors. Overexpression contributes to the malignant phenotype of a subset of human ductal pancreatic cancers. The encoded protein is a general protein kinase capable of phophorylating several known proteins. [provided by RefSeq

Other Designations

Murine thymoma viral (v-akt) homolog-2|rac protein kinase beta

Entrez GeneID

Protein Accession#

Gene Name

AKT3

Gene Alias

DKFZp434N0250, PKB-GAMMA, PKBG, PRKBG, RAC-PK-gamma, RAC-gamma, STK-2

Gene Description

v-akt murine thymoma viral oncogene homolog 3 (protein kinase B, gamma)

Omim ID

Gene Ontology

Gene Summary

The protein encoded by this gene is a member of the AKT, also called PKB, serine/threonine protein kinase family. AKT kinases are known to be regulators of cell signaling in response to insulin and growth factors. They are involved in a wide variety of biological processes including cell proliferation, differentiation, apoptosis, tumorigenesis, as well as glycogen synthesis and glucose uptake. This kinase has been shown to be stimulated by platelet-derived growth factor (PDGF), insulin, and insulin-like growth factor 1 (IGF1). Alternatively splice transcript variants encoding distinct isoforms have been described. [provided by RefSeq

Other Designations

OTTHUMP00000037911|OTTHUMP00000037912|RAC-gamma serine/threonine protein kinase|protein kinase B gamma|serine threonine protein kinase, Akt-3|v-akt murine thymoma viral oncogene homolog 3